amitriptyline 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
antidepressants, dibenzo[a,d]cycloheptane or cyclopheptene derivatives	180	50-48-6

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: amitriptyline amitriprolidine amitriptylin damitriptyline amitriptyline hydrochloride amitryptiline amitryptiline hydrochloride amitriptyline HCl amitryptiline HCl	Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines. Molecular weight: 277.41 Formula: C20H23N CLOGP: 4.85 LIPINSKI: 0 HAC: 1 HDO: 0 TPSA: 3.24 ALOGS: -4.79 ROTB: 3 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

amitriptyline
amitriprolidine
amitriptylin
damitriptyline
amitriptyline hydrochloride
amitryptiline
amitryptiline hydrochloride
amitriptyline HCl
amitryptiline HCl

Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.

Molecular weight: 277.41
Formula: C20H23N
CLOGP: 4.85
LIPINSKI: 0
HAC: 1
HDO: 0
TPSA: 3.24
ALOGS: -4.79
ROTB: 3

Status: OFP

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

Dose	Unit	Route
75	mg	O
75	mg	P

ADMET properties:

Property	Value	Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)	1	Benet LZ, Broccatelli F, Oprea TI
S (Water solubility)	31.39 mg/mL	Bocci G, Oprea TI, Benet LZ
EoM (Fraction excreted unchanged in urine)	1 %	Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose)	15.45 µM/kg/day	Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability)	48 %	Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution)	8.70 L/kg	Lombardo F, Berellini G, Obach RS
CL (Clearance)	6.10 mL/min/kg	Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma)	0.07 %	Lombardo F, Berellini G, Obach RS
t_half (Half-life)	17 hours	Lombardo F, Berellini G, Obach RS

Approvals:

Date	Agency	Company	Orphan
April 7, 1961	FDA	ASTRAZENECA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Toxicity to various agents	689.90	9.71	1607	137023	245643	63104749
Cognitive disorder	450.59	9.71	582	138048	55233	63295159
Completed suicide	426.69	9.71	966	137664	144707	63205685
Sedation complication	419.42	9.71	300	138330	13522	63336870
Sedation	396.64	9.71	456	138174	38353	63312039
Creatinine renal clearance decreased	388.08	9.71	306	138324	16002	63334390
Orthostatic hypotension	386.72	9.71	435	138195	35725	63314667
Pemphigus	374.81	9.71	5	138625	183721	63166671
Depressed level of consciousness	326.06	9.71	528	138102	61550	63288842
Blood calcium decreased	303.17	9.71	330	138300	26121	63324271
Systemic lupus erythematosus	302.97	9.71	47	138583	208871	63141521
Glossodynia	297.35	9.71	25	138605	178851	63171541
Balance disorder	270.88	9.71	581	138049	83841	63266551
Anti-cyclic citrullinated peptide antibody positive	237.67	9.71	3	138627	116209	63234183
Arthropathy	216.08	9.71	122	138508	234670	63115722
Coma	214.58	9.71	450	138180	63914	63286478
Wound	210.59	9.71	49	138581	163214	63187178
Hand deformity	201.47	9.71	50	138580	159407	63190985
Drug abuse	196.77	9.71	467	138163	72051	63278341
Electrocardiogram QRS complex prolonged	194.32	9.71	135	138495	5803	63344589
Serotonin syndrome	174.30	9.71	261	138369	28421	63321971
Duodenal ulcer perforation	167.35	9.71	5	138625	87204	63263188
Hepatic enzyme increased	167.07	9.71	119	138511	202209	63148183
Migraine	166.93	9.71	551	138079	102795	63247597
Drug ineffective for unapproved indication	148.76	9.71	267	138363	33796	63316596
Rheumatoid factor positive	148.24	9.71	9	138621	84397	63265995
Abdominal discomfort	145.92	9.71	301	138329	320584	63029808
Maternal exposure during pregnancy	143.84	9.71	161	138469	219901	63130491
Alopecia	139.26	9.71	334	138296	337202	63013190
Poisoning deliberate	135.62	9.71	144	138486	11074	63339318
Synovitis	134.34	9.71	126	138504	186792	63163600
Fall	133.24	9.71	1375	137255	390959	62959433
Contraindicated product administered	130.81	9.71	170	138460	217478	63132914
Infusion related reaction	125.03	9.71	215	138415	245306	63105086
Disturbance in attention	122.60	9.71	263	138367	37926	63312466
Folliculitis	121.98	9.71	8	138622	70309	63280083
Hypersensitivity	121.97	9.71	288	138342	292397	63057995
Muscle injury	121.00	9.71	5	138625	65340	63285052
Overdose	117.86	9.71	531	138099	114547	63235845
Impaired work ability	116.28	9.71	166	138464	17309	63333083
Pericarditis	113.09	9.71	74	138556	131505	63218887
Swelling	111.54	9.71	275	138355	275103	63075289
Mydriasis	111.33	9.71	134	138496	11822	63338570
Constipation	109.48	9.71	853	137777	224090	63126302
Anticholinergic syndrome	106.91	9.71	66	138564	2316	63348076
Exposure during pregnancy	101.37	9.71	114	138516	155433	63194959
Hypotension	98.45	9.71	968	137662	271636	63078756
Somnolence	96.76	9.71	695	137935	177990	63172402
Hyperhidrosis	94.71	9.71	476	138154	107360	63243032
Discomfort	94.23	9.71	137	138493	167237	63183155
Tension headache	93.67	9.71	83	138547	5103	63345289
Muscle twitching	93.43	9.71	160	138470	19508	63330884
Tinnitus	92.89	9.71	226	138404	35402	63314990
Neutropenia	91.12	9.71	151	138479	174854	63175538
Impaired healing	90.40	9.71	56	138574	102486	63247906
Cardiospasm	88.55	9.71	54	138576	1853	63348539
Derealisation	88.15	9.71	46	138584	1162	63349230
Pruritus genital	86.05	9.71	60	138570	2594	63347798
Palmoplantar keratoderma	86.01	9.71	54	138576	1953	63348439
Intentional overdose	85.74	9.71	355	138275	73797	63276595
Helicobacter infection	85.56	9.71	48	138582	92737	63257655
Suicidal ideation	85.30	9.71	315	138315	62106	63288286
Electrocardiogram QT prolonged	85.23	9.71	305	138325	59225	63291167
Gastric pH decreased	85.11	9.71	39	138591	735	63349657
Synovial fluid analysis	83.58	9.71	57	138573	2376	63348016
Tenosynovitis stenosans	79.75	9.71	63	138567	3301	63347091
Therapeutic product effect decreased	78.90	9.71	192	138438	192995	63157397
Anxiety	78.25	9.71	772	137858	216769	63133623
Tachycardia	77.43	9.71	482	138148	117674	63232718
Feeling jittery	77.22	9.71	119	138511	13284	63337108
Hallucination	76.90	9.71	279	138351	54538	63295854
Scleritis	76.28	9.71	69	138561	4359	63346033
Withdrawal syndrome	75.15	9.71	147	138483	19850	63330542
Pleuritic pain	74.77	9.71	90	138540	7939	63342453
Sleep terror	74.09	9.71	55	138575	2625	63347767
Feeling of despair	71.47	9.71	51	138579	2288	63348104
Irritable bowel syndrome	69.91	9.71	47	138583	82365	63268027
Nightmare	68.40	9.71	138	138492	19056	63331336
Crepitations	68.22	9.71	86	138544	7954	63342438
Dizziness	68.16	9.71	1317	137313	428608	62921784
Drug interaction	67.86	9.71	782	137848	228349	63122043
Product use issue	67.84	9.71	250	138380	220270	63130122
Platelet count decreased	67.37	9.71	93	138537	116029	63234363
Agitation	66.67	9.71	283	138347	59474	63290918
Hallucinations, mixed	65.60	9.71	66	138564	4763	63345629
Lip swelling	65.52	9.71	182	138448	30881	63319511
Cogwheel rigidity	64.95	9.71	45	138585	1925	63348467
Body tinea	64.37	9.71	44	138586	1841	63348551
H1N1 influenza	62.75	9.71	42	138588	1697	63348695
Photophobia	61.90	9.71	126	138504	17509	63332883
Dissociation	61.44	9.71	51	138579	2868	63347524
Visual impairment	61.39	9.71	354	138276	84092	63266300
Poor quality sleep	61.36	9.71	135	138495	19800	63330592
Anaemia	60.37	9.71	384	138246	293046	63057346
Rubber sensitivity	60.36	9.71	46	138584	2285	63348107
Depressed mood	60.17	9.71	209	138421	39982	63310410
Febrile neutropenia	59.98	9.71	104	138526	118345	63232047
Restless legs syndrome	59.90	9.71	128	138502	18403	63331989
Atrial tachycardia	59.54	9.71	59	138571	4181	63346211
Inhibitory drug interaction	58.36	9.71	49	138581	2800	63347592
Hip arthroplasty	58.11	9.71	16	138614	47630	63302762
Ventricular tachycardia	57.80	9.71	132	138498	19847	63330545
Eye pain	57.76	9.71	184	138446	33670	63316722
Lip pruritus	57.73	9.71	32	138598	915	63349477
Knee arthroplasty	57.71	9.71	23	138607	54183	63296209
Dystonia	57.38	9.71	106	138524	13713	63336679
Depersonalisation/derealisation disorder	56.51	9.71	36	138594	1336	63349056
Immunisation	55.95	9.71	34	138596	1159	63349233
Medication overuse headache	55.95	9.71	30	138600	802	63349590
Bradypnoea	52.84	9.71	51	138579	3499	63346893
Aspartate aminotransferase increased	52.66	9.71	72	138558	90205	63260187
Blister	52.20	9.71	130	138500	129684	63220708
Flank pain	51.50	9.71	112	138518	16298	63334094
Swelling face	50.73	9.71	273	138357	63202	63287190
Respiratory depression	50.54	9.71	100	138530	13615	63336777
Brain injury	49.97	9.71	69	138561	6974	63343418
Bone density decreased	49.63	9.71	103	138527	14509	63335883
Liver injury	49.37	9.71	36	138594	60484	63289908
Feeling of body temperature change	49.09	9.71	57	138573	4840	63345552
Insomnia	48.63	9.71	699	137931	214553	63135839
Swollen tongue	47.85	9.71	176	138454	34624	63315768
Carotid artery occlusion	47.66	9.71	55	138575	4639	63345753
Infection susceptibility increased	47.61	9.71	48	138582	3473	63346919
Mobility decreased	47.49	9.71	438	138192	120721	63229671
Feeling abnormal	46.86	9.71	513	138117	147879	63202513
Emotional disorder	46.26	9.71	95	138535	13284	63337108
Atrial fibrillation	45.20	9.71	119	138511	116517	63233875
Sacroiliitis	45.14	9.71	45	138585	3212	63347180
Disease progression	44.77	9.71	129	138501	122629	63227763
Accidental death	44.69	9.71	36	138594	1940	63348452
Hallucination, visual	44.64	9.71	117	138513	19181	63331211
Neovascularisation	44.58	9.71	29	138601	1116	63349276
Cushingoid	44.27	9.71	72	138558	8413	63341979
C-reactive protein abnormal	43.72	9.71	23	138607	46073	63304319
Persistent genital arousal disorder	43.13	9.71	18	138612	268	63350124
Somatic symptom disorder	43.00	9.71	40	138590	2620	63347772
Facial pain	42.59	9.71	80	138550	10481	63339911
Crystal nephropathy	42.17	9.71	26	138604	910	63349482
Tremor	42.13	9.71	458	138172	131781	63218611
Fibromyalgia	41.86	9.71	310	138320	80110	63270282
Malaise	40.89	9.71	1193	137437	414761	62935631
Tenosynovitis	40.86	9.71	92	138538	13703	63336689
Labelled drug-drug interaction issue	40.71	9.71	27	138603	1074	63349318
Myelosuppression	40.22	9.71	3	138627	23700	63326692
Rash	39.85	9.71	927	137703	559944	62790448
Therapeutic product ineffective	39.48	9.71	32	138598	1740	63348652
Sensory loss	39.37	9.71	76	138554	10162	63340230
Drooling	38.74	9.71	45	138585	3823	63346569
Vasculitis	38.70	9.71	107	138523	18102	63332290
Diplopia	38.70	9.71	127	138503	23601	63326791
Suicide attempt	38.32	9.71	246	138384	60672	63289720
Vision blurred	37.89	9.71	336	138294	91588	63258804
Small fibre neuropathy	37.75	9.71	19	138611	444	63349948
Joint swelling	37.56	9.71	497	138133	327169	63023223
Parosmia	37.02	9.71	56	138574	6150	63344242
Condition aggravated	36.88	9.71	637	137993	401580	62948812
Anosmia	36.87	9.71	59	138571	6801	63343591
Thrombocytopenia	36.32	9.71	188	138442	150969	63199423
Wrist deformity	36.32	9.71	33	138597	2097	63348295
General physical health deterioration	36.23	9.71	274	138356	201128	63149264
Pulmonary eosinophilia	36.18	9.71	17	138613	340	63350052
Pituitary tumour benign	36.17	9.71	32	138598	1963	63348429
Oedema	36.02	9.71	102	138528	97520	63252872
Oesophageal spasm	35.83	9.71	39	138591	3084	63347308
Heart sounds	35.80	9.71	24	138606	972	63349420
Clear cell renal cell carcinoma	35.61	9.71	28	138602	1457	63348935
Conjunctivitis	35.45	9.71	113	138517	20683	63329709
Device expulsion	35.28	9.71	16	138614	34906	63315486
Drug withdrawal syndrome	35.28	9.71	135	138495	27059	63323333
Tenderness	35.18	9.71	119	138511	22459	63327933
Cardiac arrest	34.97	9.71	332	138298	92213	63258179
Allergy to chemicals	34.92	9.71	38	138592	3004	63347388
Cardio-respiratory arrest	34.61	9.71	237	138393	59722	63290670
Glucose tolerance impaired	34.57	9.71	56	138574	6521	63343871
Cardiac failure congestive	34.54	9.71	96	138534	92337	63258055
Ill-defined disorder	34.34	9.71	80	138550	81675	63268717
Autonomic dysreflexia	34.05	9.71	16	138614	320	63350072
Psychotic disorder due to a general medical condition	33.82	9.71	15	138615	261	63350131
Prolonged expiration	33.73	9.71	24	138606	1072	63349320
Cestode infection	33.26	9.71	15	138615	272	63350120
Palpitations	32.94	9.71	384	138246	112386	63238006
Infection	32.71	9.71	331	138299	228842	63121550
Heart rate increased	32.65	9.71	332	138298	93906	63256486
Speech disorder	32.63	9.71	175	138455	40454	63309938
Myoclonus	32.50	9.71	92	138538	15776	63334616
Alanine aminotransferase increased	32.30	9.71	117	138513	103653	63246739
Telangiectasia congenital	32.28	9.71	8	138622	16	63350376
Loss of consciousness	32.21	9.71	397	138233	117724	63232668
Oedema peripheral	32.14	9.71	262	138368	189249	63161143
Oesophageal pain	32.06	9.71	40	138590	3661	63346731
Tension	31.90	9.71	37	138593	3138	63347254
Hyperlactacidaemia	31.68	9.71	35	138595	2814	63347578
Paralysis	31.56	9.71	68	138562	9832	63340560
Septic shock	31.49	9.71	61	138569	66568	63283824
Synovial cyst	31.37	9.71	70	138560	10363	63340029
Blindness	30.89	9.71	111	138519	21588	63328804
Cervix neoplasm	30.53	9.71	13	138617	204	63350188
Akathisia	30.51	9.71	64	138566	9082	63341310
Menstrual disorder	30.36	9.71	47	138583	5266	63345126
Muscle disorder	29.87	9.71	45	138585	4924	63345468
Cardiac failure	29.43	9.71	98	138532	89044	63261348
Amnesia	29.34	9.71	215	138415	55370	63295022
Adverse event	29.27	9.71	65	138565	67494	63282898
Intentional product misuse	29.00	9.71	230	138400	60687	63289705
Urinary retention	28.90	9.71	137	138493	30164	63320228
Type 2 diabetes mellitus	28.88	9.71	60	138570	63808	63286584
Multiple sclerosis relapse	28.80	9.71	193	138437	48285	63302107
Memory impairment	28.68	9.71	351	138279	103907	63246485
Dysarthria	28.43	9.71	175	138455	42536	63307856
Multiple drug therapy	27.81	9.71	37	138593	3609	63346783
Sinusitis	27.35	9.71	340	138290	226313	63124079
Pulmonary fibrosis	27.22	9.71	28	138602	39781	63310611
Live birth	27.08	9.71	11	138619	25619	63324773
Gastrointestinal disorder	26.81	9.71	172	138458	131067	63219325
Bursitis	26.72	9.71	155	138475	36886	63313506
Dyskinesia	26.49	9.71	139	138491	31863	63318529
Pain of skin	26.36	9.71	70	138560	11564	63338828
Vestibular migraine	26.34	9.71	12	138618	223	63350169
CFTR gene mutation	26.21	9.71	10	138620	116	63350276
Depressive symptom	25.88	9.71	38	138592	4064	63346328
Paraesthesia	25.85	9.71	484	138146	156482	63193910
Bone marrow failure	25.79	9.71	16	138614	29274	63321118
Vertigo	25.77	9.71	221	138409	59666	63290726
Impaired reasoning	25.71	9.71	9	138621	80	63350312
Antinuclear antibody positive	25.56	9.71	55	138575	7944	63342448
Neck pain	25.36	9.71	247	138383	69071	63281321
Neuralgia	25.29	9.71	118	138512	25808	63324584
Diaphragmatic rupture	25.09	9.71	12	138618	250	63350142
Joint effusion	24.91	9.71	88	138542	16972	63333420
Red blood cell sedimentation rate increased	24.73	9.71	36	138594	43946	63306446
Malignant neoplasm progression	24.63	9.71	94	138536	82027	63268365
Injection site erythema	24.44	9.71	96	138534	83078	63267314
Pulseless electrical activity	24.36	9.71	52	138578	7469	63342923
Multiple organ dysfunction syndrome	24.26	9.71	55	138575	56697	63293695
Blood creatinine increased	24.18	9.71	104	138526	87740	63262652
Lymphoedema	24.15	9.71	68	138562	11624	63338768
Hospitalisation	23.87	9.71	100	138530	84981	63265411
Incontinence	23.39	9.71	67	138563	11565	63338827
Therapy non-responder	23.34	9.71	86	138544	75815	63274577
Biliary sepsis	23.29	9.71	18	138612	913	63349479
Myofascial pain syndrome	23.27	9.71	27	138603	2291	63348101
Libido increased	23.25	9.71	21	138609	1324	63349068
Dry mouth	23.11	9.71	266	138364	77597	63272795
Eyelid exfoliation	23.08	9.71	10	138620	164	63350228
Forced expiratory volume decreased	23.05	9.71	40	138590	4928	63345464
Drug tolerance decreased	23.00	9.71	5	138625	17468	63332924
Injection site swelling	22.96	9.71	43	138587	47529	63302863
Diet failure	22.96	9.71	7	138623	38	63350354
Hyperaesthesia	22.95	9.71	58	138572	9300	63341092
Eye irritation	22.92	9.71	102	138528	21869	63328523
Pregnancy	22.90	9.71	28	138602	36808	63313584
Neuroleptic malignant syndrome	22.86	9.71	68	138562	11988	63338404
Premenstrual syndrome	22.72	9.71	16	138614	703	63349689
Multiple sclerosis	22.38	9.71	109	138521	24263	63326129
Hepatic function abnormal	22.29	9.71	29	138601	37113	63313279
Sternal fracture	22.20	9.71	26	138604	2228	63348164
CYP3A4 polymorphism	22.02	9.71	8	138622	80	63350312
Accidental overdose	21.95	9.71	105	138525	23204	63327188
Respiration abnormal	21.52	9.71	45	138585	6372	63344020
Neutrophil count decreased	21.50	9.71	58	138572	56348	63294044
Nodule	21.48	9.71	97	138533	20929	63329463
Anti-neutrophil cytoplasmic antibody positive vasculitis	21.47	9.71	29	138601	2870	63347522
Soft tissue injury	21.39	9.71	22	138608	1630	63348762
Renal mass	21.30	9.71	26	138604	2327	63348065
Cellulitis	21.28	9.71	273	138357	81685	63268707
Peripheral venous disease	21.26	9.71	4	138626	15473	63334919
Cerebellar stroke	20.90	9.71	11	138619	283	63350109
Mood swings	20.79	9.71	87	138543	18161	63332231
Extrapyramidal disorder	20.68	9.71	70	138560	13214	63337178
Magnesium deficiency	20.65	9.71	14	138616	578	63349814
Choanal stenosis	20.61	9.71	6	138624	27	63350365
Hypoaesthesia oral	20.58	9.71	69	138561	12964	63337428
Macular degeneration	20.53	9.71	14	138616	24362	63326030
Peritonitis	20.47	9.71	6	138624	17148	63333244
Cyanosis	20.29	9.71	82	138548	16853	63333539
Abdominal pain	20.24	9.71	808	137822	292648	63057744
Eyelid myoclonus	20.15	9.71	8	138622	104	63350288
Postural orthostatic tachycardia syndrome	20.10	9.71	19	138611	1270	63349122
Sensitivity to weather change	20.04	9.71	47	138583	7190	63343202
Drug dependence	20.03	9.71	106	138524	24377	63326015
Confusional state	19.99	9.71	666	137964	235714	63114678
Abortion spontaneous	19.96	9.71	46	138584	47149	63303243
Stomatitis	19.93	9.71	200	138430	138525	63211867
Tubulointerstitial nephritis and uveitis syndrome	19.82	9.71	10	138620	235	63350157
Restlessness	19.80	9.71	121	138509	29332	63321060
Sopor	19.55	9.71	98	138532	22066	63328326
Haemorrhage	19.52	9.71	68	138562	60954	63289438
Seizure	19.48	9.71	402	138228	132232	63218160
Rectal cancer metastatic	19.40	9.71	10	138620	246	63350146
Circulatory collapse	19.35	9.71	97	138533	21841	63328551
Renal failure	19.32	9.71	164	138466	117488	63232904
Anterograde amnesia	19.23	9.71	13	138617	534	63349858
Femoral artery dissection	19.18	9.71	6	138624	36	63350356
Naevus flammeus	19.17	9.71	8	138622	119	63350273
Hostility	19.12	9.71	22	138608	1850	63348542
Gastrointestinal haemorrhage	18.91	9.71	102	138528	81074	63269318
Hyperprolactinaemia	18.88	9.71	32	138598	3868	63346524
Disseminated intravascular coagulation	18.83	9.71	9	138621	19042	63331350
Psychotic symptom	18.80	9.71	20	138610	1541	63348851
Death	18.80	9.71	649	137981	373732	62976660
Subclavian artery embolism	18.75	9.71	5	138625	15	63350377
Personality disorder	18.62	9.71	40	138590	5771	63344621
Skin necrosis	18.34	9.71	4	138626	13946	63336446
Coma scale abnormal	18.30	9.71	37	138593	5116	63345276
Vascular malformation	18.26	9.71	11	138619	369	63350023
Muscle rigidity	18.26	9.71	61	138569	11439	63338953
Dental restoration failure	18.23	9.71	16	138614	971	63349421
White blood cell count decreased	18.18	9.71	205	138425	138899	63211493
Thymus disorder	17.88	9.71	10	138620	291	63350101
Sinus tachycardia	17.80	9.71	102	138528	24166	63326226
Respiratory arrest	17.64	9.71	127	138503	32518	63317874
Paranasal cyst	17.56	9.71	11	138619	396	63349996
Visual snow syndrome	17.48	9.71	6	138624	50	63350342
Delirium	17.47	9.71	178	138452	50363	63300029
Paradoxical drug reaction	17.43	9.71	32	138598	4120	63346272
Lip dry	17.41	9.71	6	138624	15464	63334928
Mood altered	17.36	9.71	71	138559	14672	63335720
Pancytopenia	17.35	9.71	132	138498	96801	63253591
Poliomyelitis	17.28	9.71	6	138624	52	63350340
Mental disorder	17.12	9.71	106	138524	25813	63324579
Respiratory acidosis	16.87	9.71	42	138588	6673	63343719
Purpura	16.86	9.71	59	138571	11326	63339066
Hyperthermia	16.76	9.71	51	138579	9105	63341287
Ventricular arrhythmia	16.70	9.71	30	138600	3798	63346594
Blood bilirubin increased	16.69	9.71	35	138595	37105	63313287
Secondary adrenocortical insufficiency	16.68	9.71	18	138612	1410	63348982
SLE arthritis	16.67	9.71	13	138617	668	63349724
Lichen sclerosus	16.63	9.71	16	138614	1093	63349299
Parkinsonian rest tremor	16.61	9.71	7	138623	107	63350285
Vaccination site oedema	16.49	9.71	4	138626	7	63350385
Bradycardia	16.19	9.71	237	138393	72990	63277402
Vaccination site bruising	16.14	9.71	4	138626	8	63350384
Enlarged uvula	16.09	9.71	8	138622	182	63350210
Leukopenia	15.93	9.71	101	138529	77189	63273203
Burning feet syndrome	15.85	9.71	6	138624	68	63350324
Viral diarrhoea	15.82	9.71	8	138622	189	63350203
Product dispensing error	15.78	9.71	54	138576	10251	63340141
Post-traumatic neck syndrome	15.75	9.71	21	138609	2053	63348339
Psoriatic arthropathy	15.74	9.71	126	138504	91394	63258998
Hot flush	15.73	9.71	176	138454	50983	63299409
Mania	15.72	9.71	61	138569	12306	63338086
Oral herpes	15.60	9.71	104	138526	25970	63324422
Appetite disorder	15.54	9.71	43	138587	7278	63343114
Drug intolerance	15.50	9.71	535	138095	308126	63042266
Sepsis	15.48	9.71	238	138392	152885	63197507
Blood cholesterol increased	15.47	9.71	131	138499	93901	63256491
Injury	15.47	9.71	95	138535	73152	63277240
Caesarean section	15.42	9.71	9	138621	17023	63333369
Eye pruritus	15.38	9.71	81	138549	18590	63331802
Polymenorrhoea	15.34	9.71	16	138614	1205	63349187
Foetal exposure during pregnancy	15.33	9.71	29	138601	31933	63318459
Unevaluable event	15.29	9.71	59	138571	51327	63299065
Dry eye	15.28	9.71	146	138484	40615	63309777
Vaccination site pruritus	15.25	9.71	4	138626	11	63350381
Movement disorder	15.21	9.71	90	138540	21571	63328821
Treatment failure	15.20	9.71	325	138305	198718	63151674
Pulmonary hypertension	15.05	9.71	37	138593	37086	63313306
Renal impairment	15.03	9.71	122	138508	88233	63262159
Adiposis dolorosa	14.88	9.71	9	138621	304	63350088
Premature baby	14.85	9.71	14	138616	20721	63329671
Hyperlipidaemia	14.84	9.71	83	138547	19488	63330904
Muscle spasms	14.78	9.71	446	138184	155704	63194688
Subarachnoid haemorrhage	14.67	9.71	66	138564	14217	63336175
Concussion	14.65	9.71	49	138581	9195	63341197
Vulvovaginal swelling	14.55	9.71	11	138619	540	63349852
Environmental exposure	14.52	9.71	6	138624	87	63350305
Impaired quality of life	14.39	9.71	64	138566	13719	63336673
Abnormal loss of weight	14.35	9.71	36	138594	5746	63344646
Limb injury	14.28	9.71	100	138530	25377	63325015
Immune thrombocytopenia	14.18	9.71	53	138577	10503	63339889
Irritability	14.18	9.71	118	138512	31576	63318816
Myoglobin urine	14.11	9.71	4	138626	16	63350376
Oxalosis	14.04	9.71	5	138625	47	63350345
Slow speech	14.01	9.71	17	138613	1512	63348880
Migraine with aura	13.96	9.71	23	138607	2717	63347675
Asthenia	13.93	9.71	690	137940	382914	62967478
Genital infection female	13.87	9.71	6	138624	98	63350294
Aphasia	13.78	9.71	121	138509	32879	63317513
Ulcer	13.78	9.71	101	138529	26006	63324386
Injection site pain	13.72	9.71	200	138430	129600	63220792
Agranulocytosis	13.71	9.71	21	138609	25113	63325279
Deep vein thrombosis	13.67	9.71	117	138513	83683	63266709
Plasma cell myeloma	13.62	9.71	37	138593	35868	63314524
Laryngeal dyspnoea	13.55	9.71	7	138623	173	63350219
Dehydration	13.54	9.71	282	138348	173072	63177320
Hypoglycaemic seizure	13.38	9.71	10	138620	482	63349910
Diaphragmatic paralysis	13.34	9.71	11	138619	613	63349779
Depression	13.29	9.71	540	138090	195952	63154440
Procedural anxiety	13.19	9.71	12	138618	764	63349628
Ear haemorrhage	13.18	9.71	16	138614	1424	63348968
Pyrexia	13.14	9.71	868	137762	469610	62880782
Muscular weakness	13.10	9.71	355	138275	121998	63228394
Enthesopathy	13.07	9.71	45	138585	8569	63341823
Pneumonia	12.87	9.71	842	137788	455925	62894467
Nail injury	12.81	9.71	11	138619	648	63349744
Stress	12.79	9.71	212	138418	66955	63283437
Grip strength decreased	12.77	9.71	18	138612	22269	63328123
Pleural effusion	12.72	9.71	136	138494	93074	63257318
Chondropathy	12.66	9.71	20	138610	2280	63348112
Maternal condition affecting foetus	12.60	9.71	7	138623	201	63350191
Herpes zoster meningoencephalitis	12.58	9.71	8	138622	296	63350096
Hypoalbuminaemia	12.58	9.71	5	138625	11800	63338592
Naevus haemorrhage	12.55	9.71	6	138624	125	63350267
Autonomic neuropathy	12.48	9.71	14	138616	1145	63349247
Judgement impaired	12.47	9.71	12	138618	820	63349572
HLA marker study positive	12.45	9.71	7	138623	206	63350186
Atelectasis	12.44	9.71	85	138545	21398	63328994
Mouth swelling	12.28	9.71	30	138600	4710	63345682
Rheumatoid arthritis	12.26	9.71	442	138188	253377	63097015
Pericardial effusion	12.15	9.71	30	138600	30028	63320364
Axonal neuropathy	12.14	9.71	13	138617	1009	63349383
Onychophagia	12.13	9.71	5	138625	72	63350320
Angioedema	12.13	9.71	159	138471	47806	63302586
Gait inability	12.08	9.71	67	138563	52892	63297500
Injection site bruising	11.91	9.71	49	138581	41861	63308531
Urticaria aquagenic	11.91	9.71	4	138626	31	63350361
IIIrd nerve paresis	11.89	9.71	6	138624	141	63350251
Acquired diaphragmatic eventration	11.88	9.71	9	138621	443	63349949
Muscle contracture	11.82	9.71	15	138615	1396	63348996
Aorta hypoplasia	11.81	9.71	6	138624	143	63350249
Mastoiditis	11.80	9.71	13	138617	1042	63349350
Urticaria cholinergic	11.80	9.71	4	138626	32	63350360
Injection site reaction	11.79	9.71	77	138553	58447	63291945
Cystitis interstitial	11.78	9.71	16	138614	1592	63348800
Schizophrenia	11.77	9.71	48	138582	9904	63340488
Metastases to central nervous system	11.76	9.71	7	138623	13098	63337294
Overlap syndrome	11.72	9.71	12	138618	884	63349508
Dysphemia	11.71	9.71	21	138609	2654	63347738
Diarrhoea	11.67	9.71	1376	137254	713990	62636402
Lower limb fracture	11.59	9.71	22	138608	24199	63326193
Electrocardiogram QRS complex shortened	11.59	9.71	9	138621	460	63349932
Pancreatitis relapsing	11.57	9.71	12	138618	898	63349494
Complication associated with device	11.54	9.71	12	138618	16966	63333426
Flat affect	11.50	9.71	15	138615	1435	63348957
Linear IgA disease	11.49	9.71	15	138615	1436	63348956
Suspected suicide	11.48	9.71	36	138594	6532	63343860
Respiratory failure	11.46	9.71	155	138475	101703	63248689
Pneumocystis jirovecii pneumonia	11.44	9.71	12	138618	16902	63333490
Chemical burns of eye	11.38	9.71	5	138625	85	63350307
Loss of personal independence in daily activities	11.33	9.71	147	138483	97143	63253249
Glomerulonephritis minimal lesion	11.28	9.71	7	138623	248	63350144
Myelodysplastic syndrome	11.21	9.71	12	138618	16742	63333650
Lymphocytosis	11.21	9.71	21	138609	2746	63347646
Abulia	11.19	9.71	9	138621	484	63349908
Hyperacusis	11.12	9.71	18	138612	2095	63348297
Product dose omission issue	11.10	9.71	409	138221	233904	63116488
Food refusal	11.05	9.71	8	138622	367	63350025
Emphysematous cystitis	11.04	9.71	6	138624	165	63350227
Infrapatellar fat pad inflammation	10.97	9.71	6	138624	167	63350225
Peripheral circulatory failure	10.95	9.71	12	138618	956	63349436
Menstruation delayed	10.88	9.71	16	138614	1713	63348679
Metastases to liver	10.86	9.71	22	138608	23617	63326775
Hypochromic anaemia	10.85	9.71	17	138613	1925	63348467
Open angle glaucoma	10.82	9.71	7	138623	267	63350125
Pulmonary toxicity	10.71	9.71	45	138585	9410	63340982
Haemoglobin decreased	10.69	9.71	239	138391	145246	63205146
Hypovolaemia	10.61	9.71	5	138625	10668	63339724
Metabolic myopathy	10.59	9.71	3	138627	12	63350380
Ovarian adhesion	10.59	9.71	3	138627	12	63350380
Blood creatine phosphokinase decreased	10.57	9.71	9	138621	524	63349868
Hypercholesterolaemia	10.55	9.71	19	138611	21315	63329077
Heliotrope rash	10.53	9.71	6	138624	181	63350211
Systemic infection	10.52	9.71	28	138602	4632	63345760
Intestinal adenocarcinoma	10.50	9.71	6	138624	182	63350210
Delusion	10.50	9.71	53	138577	11964	63338428
Ankylosing spondylitis	10.46	9.71	48	138582	10426	63339966
Platelet count increased	10.45	9.71	14	138616	17697	63332695
Nail bed tenderness	10.43	9.71	8	138622	401	63349991
Hiccups	10.40	9.71	18	138612	2213	63348179
Pulmonary arterial hypertension	10.38	9.71	21	138609	22556	63327836
Red blood cell sedimentation rate abnormal	10.34	9.71	17	138613	19765	63330627
Vitreous detachment	10.30	9.71	17	138613	2010	63348382
Central obesity	10.26	9.71	13	138617	1208	63349184
Therapeutic response changed	10.20	9.71	12	138618	1033	63349359
Synovial disorder	10.19	9.71	17	138613	2028	63348364
Hypoventilation	10.17	9.71	28	138602	4726	63345666
Hypercalcaemia	10.14	9.71	30	138600	28292	63322100
Metastases to bone	10.14	9.71	19	138611	21000	63329392
Pharyngeal mass	10.13	9.71	7	138623	298	63350094
Bacteriuria	10.13	9.71	12	138618	1041	63349351
Cholecystitis chronic	10.08	9.71	5	138625	10356	63340036
Staphylococcal infection	10.08	9.71	51	138579	41205	63309187
Disorientation	10.06	9.71	131	138499	39321	63311071
Aptyalism	10.05	9.71	9	138621	561	63349831
Blood calcium increased	9.90	9.71	4	138626	9346	63341046
Pharyngeal enanthema	9.87	9.71	4	138626	55	63350337
Metastases to lung	9.87	9.71	8	138622	12742	63337650
Cytokine release syndrome	9.86	9.71	10	138620	14304	63336088
Conduction disorder	9.85	9.71	14	138616	1453	63348939
Ear pain	9.79	9.71	43	138587	36075	63314317

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Migraine	303.01	11.68	222	46182	17256	34893271
Toxicity to various agents	271.29	11.68	726	45678	199636	34710891
Serotonin syndrome	221.25	11.68	195	46209	19738	34890789
Cardiospasm	163.45	11.68	66	46338	1522	34909005
Tension headache	157.05	11.68	78	46326	2964	34907563
Palmoplantar keratoderma	147.05	11.68	65	46339	1888	34908639
Facial pain	145.34	11.68	79	46325	3625	34906902
Completed suicide	137.72	11.68	361	46043	97807	34812720
Pruritus genital	136.43	11.68	64	46340	2140	34908387
Sleep terror	136.40	11.68	65	46339	2253	34908274
Coma	136.25	11.68	229	46175	45449	34865078
Anosmia	120.67	11.68	72	46332	3952	34906575
Muscle twitching	118.77	11.68	103	46301	10195	34900332
Overdose	117.77	11.68	325	46079	90734	34819793
Atrial tachycardia	116.60	11.68	68	46336	3577	34906950
Carotid artery occlusion	112.41	11.68	67	46337	3670	34906857
Immunisation	111.67	11.68	45	46359	1032	34909495
Drug abuse	110.14	11.68	335	46069	98761	34811766
Disturbance in attention	106.77	11.68	151	46253	25794	34884733
Pain of skin	102.22	11.68	76	46328	6033	34904494
Electrocardiogram QRS complex prolonged	100.57	11.68	69	46335	4825	34905702
Sedation	95.06	11.68	128	46276	20878	34889649
Coombs positive haemolytic anaemia	91.85	11.68	38	46366	934	34909593
Vasculitis	84.56	11.68	89	46315	11207	34899320
Poisoning deliberate	81.57	11.68	74	46330	7770	34902757
Nightmare	79.78	11.68	97	46307	14294	34896233
Eye pruritus	70.81	11.68	67	46337	7422	34903105
Lymphadenitis	70.65	11.68	40	46364	1988	34908539
Hyperhidrosis	70.53	11.68	241	46163	75451	34835076
Intentional overdose	69.92	11.68	169	46235	43505	34867022
Nephrolithiasis	63.89	11.68	131	46273	30202	34880325
Cognitive disorder	62.91	11.68	126	46278	28567	34881960
Tinnitus	61.46	11.68	102	46302	20016	34890511
Hallucination	60.83	11.68	178	46226	51320	34859207
Pericarditis	60.53	11.68	76	46328	11569	34898958
Head discomfort	59.63	11.68	47	46357	4069	34906458
Subarachnoid haemorrhage	58.70	11.68	78	46326	12557	34897970
Platelet count decreased	58.56	11.68	44	46360	119673	34790854
Lip swelling	56.63	11.68	87	46317	15993	34894534
Ventricular tachycardia	56.23	11.68	115	46289	26464	34884063
Memory impairment	53.35	11.68	152	46252	43166	34867361
Product used for unknown indication	53.10	11.68	26	46378	957	34909570
Rash papular	51.71	11.68	66	46338	10212	34900315
Visual impairment	51.47	11.68	133	46271	35669	34874858
Blindness	51.26	11.68	80	46324	14906	34895621
Anxiety	50.50	11.68	263	46141	99165	34811362
Disease progression	49.99	11.68	42	46362	108035	34802492
Diplopia	49.58	11.68	84	46320	16759	34893768
Amnesia	48.21	11.68	108	46296	26455	34884072
Allodynia	47.97	11.68	23	46381	808	34909719
Suicide attempt	46.95	11.68	136	46268	38980	34871547
Palpitations	44.17	11.68	135	46269	39851	34870676
Feeling abnormal	41.35	11.68	180	46224	63055	34847472
Intentional product misuse	40.52	11.68	143	46261	45468	34865059
Anaemia	39.80	11.68	167	46237	233168	34677359
Foetal disorder	39.17	11.68	20	46384	806	34909721
Headache	38.82	11.68	422	45982	200213	34710314
Insomnia	38.55	11.68	253	46151	103654	34806873
White blood cell count decreased	38.40	11.68	42	46362	95403	34815124
Confusional state	37.11	11.68	322	46082	143838	34766689
Somnolence	36.16	11.68	262	46142	110854	34799673
Pain	35.76	11.68	422	45982	204253	34706274
Transient ischaemic attack	35.07	11.68	98	46306	27515	34883012
Delusion of replacement	34.00	11.68	11	46393	130	34910397
Death	33.75	11.68	352	46052	397697	34512830
Neutropenia neonatal	33.07	11.68	17	46387	695	34909832
Heart rate increased	32.68	11.68	135	46269	46208	34864319
Substance abuse	32.20	11.68	45	46359	7596	34902931
Dry skin	31.22	11.68	102	46302	31185	34879342
Thrombocytopenia	31.05	11.68	105	46299	156142	34754385
Colour blindness acquired	30.53	11.68	9	46395	76	34910451
Sepsis	30.40	11.68	116	46288	166445	34744082
Patient dissatisfaction with treatment	30.32	11.68	9	46395	78	34910449
Haemoglobin decreased	29.19	11.68	74	46330	120698	34789829
Drug ineffective for unapproved indication	28.98	11.68	83	46321	23632	34886895
Renal failure	28.56	11.68	84	46320	130473	34780054
Carbon dioxide abnormal	27.05	11.68	10	46394	180	34910347
Muscular weakness	26.72	11.68	177	46227	72720	34837807
Tachycardia	26.49	11.68	198	46206	84574	34825953
Febrile neutropenia	25.81	11.68	94	46310	136755	34773772
Hypotension	25.43	11.68	181	46223	221468	34689059
Withdrawal syndrome	24.13	11.68	52	46352	12403	34898124
Abdominal pain upper	24.07	11.68	170	46234	71320	34839207
Suicidal ideation	23.43	11.68	111	46293	40277	34870250
Haemolysis	23.33	11.68	40	46364	8054	34902473
HIV peripheral neuropathy	23.05	11.68	6	46398	30	34910497
Intentional product use issue	22.99	11.68	147	46257	59669	34850858
Delirium	22.74	11.68	117	46287	43874	34866653
Chemical submission	21.99	11.68	6	46398	37	34910490
Interstitial lung disease	21.83	11.68	33	46371	65249	34845278
Alopecia	21.31	11.68	76	46328	24279	34886248
Neck pain	21.25	11.68	78	46326	25271	34885256
Back pain	21.17	11.68	251	46153	121538	34788989
Drug withdrawal syndrome neonatal	21.04	11.68	25	46379	3594	34906933
Alcoholic ketoacidosis	20.98	11.68	5	46399	16	34910511
Foetal exposure during pregnancy	20.86	11.68	103	46301	37998	34872529
Oedema peripheral	20.85	11.68	85	46319	119727	34790800
Respiratory failure	20.85	11.68	74	46330	108498	34802029
Hyperaesthesia	20.61	11.68	28	46376	4602	34905925
Drug dispensed to wrong patient	20.07	11.68	11	46393	513	34910014
Depression	20.02	11.68	207	46197	96891	34813636
Mydriasis	19.86	11.68	35	46369	7202	34903325
Femoral nerve palsy	19.82	11.68	6	46398	56	34910471
Device effect decreased	19.74	11.68	4	46400	4	34910523
Anophthalmos	19.74	11.68	4	46400	4	34910523
Sopor	19.44	11.68	47	46357	12089	34898438
Sitting disability	19.36	11.68	8	46396	196	34910331
Brain stem syndrome	19.29	11.68	11	46393	554	34909973
Type III immune complex mediated reaction	19.15	11.68	9	46395	302	34910225
Astigmatism	19.14	11.68	14	46390	1083	34909444
Angioedema	19.04	11.68	99	46305	37275	34873252
Pulmonary embolism	18.71	11.68	59	46345	89687	34820840
Multiple organ dysfunction syndrome	18.42	11.68	47	46357	76519	34834008
Venous angioma of brain	17.90	11.68	5	46399	34	34910493
Behaviour disorder	17.90	11.68	27	46377	4883	34905644
Hallucination, visual	17.74	11.68	58	46346	17733	34892794
Agoraphobia	17.73	11.68	8	46396	244	34910283
Peripheral swelling	17.63	11.68	167	46237	76374	34834153
Quality of life decreased	17.51	11.68	24	46380	3977	34906550
Thoracic vertebral fracture	17.36	11.68	16	46388	1714	34908813
Pneumonia	17.23	11.68	359	46045	362268	34548259
Rash	17.20	11.68	201	46203	222551	34687976
Acute lung injury	17.20	11.68	15	46389	1495	34909032
Myoclonus	16.52	11.68	50	46354	14675	34895852
Acute psychosis	16.50	11.68	16	46388	1827	34908700
Blood bilirubin increased	16.35	11.68	16	46388	38280	34872247
Pulmonary artery stenosis	16.18	11.68	8	46396	301	34910226
Onycholysis	16.13	11.68	11	46393	761	34909766
Haematuria	16.08	11.68	26	46378	50040	34860487
CADASIL	16.03	11.68	6	46398	112	34910415
Neutrophil count decreased	15.98	11.68	27	46377	51077	34859450
Dry age-related macular degeneration	15.88	11.68	6	46398	115	34910412
Multiple drug therapy	15.81	11.68	9	46395	452	34910075
Adjustment disorder with disturbance of conduct	15.79	11.68	6	46398	117	34910410
Brugada syndrome	15.77	11.68	11	46393	790	34909737
Burning sensation	15.75	11.68	57	46347	18337	34892190
Bradyphrenia	15.56	11.68	25	46379	4773	34905754
Velopharyngeal incompetence	15.53	11.68	4	46400	19	34910508
Clumsiness	15.43	11.68	15	46389	1717	34908810
Pleural effusion	15.37	11.68	56	46348	81490	34829037
Ascites	15.13	11.68	24	46380	46547	34863980
Cardiotoxicity	15.10	11.68	27	46377	5621	34904906
Depressed level of consciousness	15.07	11.68	103	46301	42738	34867789
Blood urea increased	15.03	11.68	11	46393	30353	34880174
Blood creatinine increased	14.92	11.68	70	46334	94906	34815621
Mast cell degranulation present	14.81	11.68	5	46399	68	34910459
Victim of crime	14.56	11.68	8	46396	375	34910152
Haemoptysis	14.52	11.68	15	46389	34991	34875536
Urticaria	14.46	11.68	39	46365	62338	34848189
Skull fracture	14.39	11.68	11	46393	910	34909617
Medical device site dryness	14.35	11.68	4	46400	27	34910500
Electric shock	14.30	11.68	6	46398	153	34910374
Pulmonary hypertension	14.21	11.68	5	46399	20919	34889608
Neurosis	14.15	11.68	6	46398	157	34910370
Ventricular hypoplasia	14.07	11.68	5	46399	80	34910447
Atrial fibrillation	13.98	11.68	100	46304	122293	34788234
Hyperthermia	13.88	11.68	38	46366	10539	34899988
General physical health deterioration	13.61	11.68	107	46297	128162	34782365
Deep vein thrombosis	13.52	11.68	43	46361	65205	34845322
Disseminated intravascular coagulation	13.52	11.68	6	46398	21810	34888717
Sensorimotor disorder	13.49	11.68	8	46396	434	34910093
Depressed mood	13.39	11.68	56	46348	19261	34891266
Cardiac failure congestive	13.30	11.68	61	46343	83209	34827318
Hypomania	13.23	11.68	16	46388	2343	34908184
Blood lactate dehydrogenase increased	13.22	11.68	7	46397	22983	34887544
Post herpetic neuralgia	13.17	11.68	11	46393	1034	34909493
Agitation	13.10	11.68	125	46279	57274	34853253
Neuralgia	13.08	11.68	47	46357	15066	34895461
Cyclic vomiting syndrome	13.06	11.68	4	46400	39	34910488
Lipids increased	13.03	11.68	11	46393	1049	34909478
Diarrhoea	12.89	11.68	407	45997	389505	34521022
Insulin resistance	12.87	11.68	9	46395	649	34909878
Neovascular age-related macular degeneration	12.78	11.68	6	46398	201	34910326
Mucosal dryness	12.76	11.68	12	46392	1319	34909208
Lid lag	12.73	11.68	3	46401	9	34910518
Agitation neonatal	12.71	11.68	11	46393	1085	34909442
Neutropenia	12.66	11.68	140	46264	156638	34753889
Leukopenia	12.63	11.68	42	46362	62814	34847713
Renal pain	12.56	11.68	18	46386	3110	34907417
Tongue spasm	12.54	11.68	4	46400	45	34910482
Tremor	12.53	11.68	166	46238	82421	34828106
Dysarthria	12.46	11.68	84	46320	34698	34875829
Benzodiazepine drug level therapeutic	12.31	11.68	4	46400	48	34910479
Anaphylactic shock	12.30	11.68	3	46401	15938	34894589
Generalised tonic-clonic seizure	12.13	11.68	58	46346	21116	34889411
Multiple sclerosis	12.03	11.68	27	46377	6618	34903909
Blood creatine phosphokinase increased	12.01	11.68	26	46378	44831	34865696
Victim of homicide	12.01	11.68	5	46399	125	34910402
Bursitis	11.99	11.68	24	46380	5434	34905093
Mucocutaneous disorder	11.93	11.68	5	46399	127	34910400
Aspartate aminotransferase increased	11.84	11.68	48	46356	67735	34842792
Haematoma	11.76	11.68	10	46394	25595	34884932
Sports injury	11.75	11.68	5	46399	132	34910395
Decreased appetite	11.75	11.68	153	46251	166239	34744288
Liver disorder	11.70	11.68	16	46388	32981	34877546

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Toxicity to various agents	805.01	9.95	2308	164000	419232	79158848
Cognitive disorder	522.93	9.95	686	165622	69240	79508840
Sedation	469.31	9.95	560	165748	51335	79526745
Sedation complication	454.50	9.95	325	165983	15344	79562736
Completed suicide	445.13	9.95	1322	164986	244445	79333635
Migraine	393.82	9.95	677	165631	86816	79491264
Creatinine renal clearance decreased	379.93	9.95	316	165992	18686	79559394
Serotonin syndrome	327.68	9.95	436	165872	44591	79533489
Coma	312.36	9.95	665	165643	99984	79478096
Orthostatic hypotension	304.73	9.95	473	165835	55691	79522389
Depressed level of consciousness	300.41	9.95	639	165669	96013	79482067
Electrocardiogram QRS complex prolonged	294.36	9.95	216	166092	10617	79567463
Balance disorder	288.31	9.95	637	165671	98220	79479860
Blood calcium decreased	283.74	9.95	341	165967	31478	79546602
Cardiospasm	215.72	9.95	115	166193	3186	79574894
Disturbance in attention	210.25	9.95	379	165929	50422	79527658
Tension headache	210.10	9.95	150	166158	7061	79571019
Drug abuse	205.01	9.95	775	165533	161916	79416164
Palmoplantar keratoderma	200.28	9.95	114	166194	3602	79574478
Overdose	197.26	9.95	834	165474	183372	79394708
Pruritus genital	193.03	9.95	119	166189	4367	79573713
Poisoning deliberate	188.22	9.95	214	166094	18614	79559466
Pemphigus	188.01	9.95	4	166304	99578	79478502
Muscle twitching	185.08	9.95	243	166065	24521	79553559
Sleep terror	183.58	9.95	115	166193	4343	79573737
Tinnitus	158.86	9.95	311	165997	44022	79534058
Anti-cyclic citrullinated peptide antibody positive	158.31	9.95	3	166305	83140	79494940
Facial pain	148.99	9.95	155	166153	12195	79565885
Platelet count decreased	144.91	9.95	116	166192	194548	79383532
Atrial tachycardia	141.28	9.95	118	166190	7015	79571065
Immunisation	140.22	9.95	75	166233	2092	79575988
Hyperhidrosis	138.84	9.95	655	165653	150837	79427243
Systemic lupus erythematosus	137.24	9.95	41	166267	121108	79456972
Drug ineffective for unapproved indication	133.61	9.95	316	165992	50922	79527158
Carotid artery occlusion	132.14	9.95	117	166191	7530	79570550
Intentional overdose	131.95	9.95	503	165805	105457	79472623
Anosmia	130.76	9.95	124	166184	8720	79569360
Glossodynia	130.47	9.95	28	166280	103309	79474771
Anxiety	125.00	9.95	917	165391	247595	79330485
Neutropenia	122.10	9.95	261	166047	287449	79290631
Anaemia	120.63	9.95	498	165810	444517	79133563
Mydriasis	119.44	9.95	165	166143	17478	79560602
Arthropathy	118.05	9.95	117	166191	176994	79401086
Constipation	116.34	9.95	997	165311	282053	79296027
Febrile neutropenia	114.30	9.95	191	166117	230808	79347272
Duodenal ulcer perforation	113.32	9.95	6	166302	66205	79511875
Lip swelling	111.79	9.95	257	166051	40654	79537426
Hallucination	111.69	9.95	413	165895	85332	79492748
Anticholinergic syndrome	109.56	9.95	77	166231	3534	79574546
Nightmare	108.33	9.95	194	166114	25667	79552413
Impaired work ability	105.65	9.95	165	166143	19516	79558564
Pain of skin	103.97	9.95	140	166168	14473	79563607
Visual impairment	102.32	9.95	422	165886	91709	79486371
Fall	99.86	9.95	1498	164810	486131	79091949
Somnolence	99.34	9.95	844	165464	238137	79339943
Wound	98.65	9.95	60	166248	116119	79461961
Ventricular tachycardia	95.94	9.95	246	166062	41689	79536391
Vasculitis	95.94	9.95	181	166127	24921	79553159
Hand deformity	93.48	9.95	50	166258	103869	79474211
Feeling abnormal	90.87	9.95	606	165702	158593	79419487
Withdrawal syndrome	89.74	9.95	183	166125	26671	79551409
Rheumatoid factor positive	89.59	9.95	10	166298	59829	79518251
Disease progression	88.83	9.95	155	166153	184207	79393873
Suicidal ideation	85.81	9.95	351	165957	75989	79502091
Synovial fluid analysis	85.13	9.95	56	166252	2303	79575777
Tenosynovitis stenosans	85.04	9.95	62	166246	3016	79575064
Rubber sensitivity	81.94	9.95	49	166259	1700	79576380
Synovitis	81.84	9.95	117	166191	150617	79427463
Gastric pH decreased	81.79	9.95	39	166269	847	79577233
Tachycardia	81.48	9.95	642	165666	177126	79400954
Muscle injury	81.26	9.95	5	166303	48556	79529524
Feeling jittery	80.85	9.95	116	166192	12725	79565355
Thrombocytopenia	80.06	9.95	284	166024	264975	79313105
Scleritis	77.98	9.95	68	166240	4288	79573792
Derealisation	76.74	9.95	46	166262	1603	79576477
Cytomegalovirus infection	75.79	9.95	3	166305	42641	79535439
Diplopia	75.20	9.95	195	166113	33271	79544809
Poor quality sleep	74.93	9.95	154	166154	22568	79555512
Palpitations	73.48	9.95	484	165824	126126	79451954
Depressed mood	72.13	9.95	244	166064	48236	79529844
Aspartate aminotransferase increased	71.97	9.95	111	166197	138530	79439550
Dizziness	71.93	9.95	1517	164791	524924	79053156
Blindness	70.70	9.95	172	166136	28211	79549869
Coombs positive haemolytic anaemia	70.01	9.95	38	166270	1092	79576988
Eye pruritus	69.71	9.95	141	166167	20429	79557651
Insomnia	69.67	9.95	800	165508	244370	79333710
Fibromyalgia	68.53	9.95	291	166017	64049	79514031
Hypersensitivity	68.15	9.95	298	166010	261941	79316139
Myelosuppression	67.88	9.95	4	166304	40292	79537788
Suicide attempt	67.66	9.95	347	165961	82585	79495495
Electrocardiogram QT prolonged	67.45	9.95	369	165939	90017	79488063
Mobility decreased	66.08	9.95	459	165849	121716	79456364
Folliculitis	65.95	9.95	17	166291	55363	79522717
Pain	64.88	9.95	1923	164385	701879	78876201
Memory impairment	64.75	9.95	427	165881	111307	79466773
Body tinea	64.45	9.95	43	166265	1811	79576269
Maternal exposure during pregnancy	63.77	9.95	117	166191	136421	79441659
Atrial fibrillation	63.69	9.95	206	166102	197680	79380400
Medication overuse headache	63.07	9.95	33	166275	879	79577201
Feeling of despair	62.89	9.95	50	166258	2771	79575309
Pleuritic pain	62.88	9.95	91	166217	10061	79568019
Amnesia	62.42	9.95	279	166029	62778	79515302
Swelling face	60.22	9.95	301	166007	70911	79507169
Sepsis	59.68	9.95	324	165984	269104	79308976
Heart rate increased	58.63	9.95	442	165866	120282	79457798
Hallucinations, mixed	58.34	9.95	72	166236	6827	79571253
Hepatic enzyme increased	58.14	9.95	191	166117	182419	79395661
Malaise	57.88	9.95	1383	164925	488486	79089594
Eye pain	57.56	9.95	191	166117	37387	79540693
Lip pruritus	57.43	9.95	31	166277	881	79577199
C-reactive protein abnormal	57.31	9.95	15	166293	48352	79529728
Swollen tongue	57.06	9.95	207	166101	42363	79535717
Alanine aminotransferase increased	56.03	9.95	164	166144	162406	79415674
Flank pain	54.58	9.95	125	166183	19719	79558361
Multiple organ dysfunction syndrome	54.43	9.95	105	166203	120141	79457939
Photophobia	53.93	9.95	127	166181	20401	79557679
Crepitations	53.79	9.95	84	166224	9933	79568147
General physical health deterioration	53.53	9.95	345	165963	274893	79303187
Hallucination, visual	53.42	9.95	170	166138	32559	79545521
H1N1 influenza	52.66	9.95	43	166265	2476	79575604
Cardiac failure congestive	52.53	9.95	139	166169	142263	79435817
Restless legs syndrome	52.46	9.95	124	166184	19968	79558112
Agitation	52.38	9.95	372	165936	99343	79478737
Tremor	51.94	9.95	563	165745	169520	79408560
Renal failure	51.81	9.95	229	166079	200739	79377341
Dissociation	51.28	9.95	52	166256	3969	79574111
Cogwheel rigidity	50.89	9.95	46	166262	3042	79575038
Blood creatinine increased	50.87	9.95	160	166148	154897	79423183
Oedema peripheral	50.20	9.95	314	165994	251974	79326106
Malignant neoplasm progression	49.96	9.95	133	166175	135857	79442223
Subarachnoid haemorrhage	49.36	9.95	137	166171	24328	79553752
Infusion related reaction	49.27	9.95	280	166028	229957	79348123
White blood cell count decreased	48.87	9.95	214	166094	188074	79390006
Depersonalisation/derealisation disorder	48.05	9.95	36	166272	1826	79576254
Neutrophil count decreased	48.01	9.95	76	166232	93883	79484197
Intentional product misuse	47.09	9.95	350	165958	94815	79483265
Bone density decreased	47.03	9.95	93	166215	13254	79564826
Emotional disorder	45.67	9.95	96	166212	14291	79563789
Confusional state	45.18	9.95	922	165386	317075	79261005
Rheumatic fever	44.70	9.95	4	166304	28521	79549559
Dystonia	44.34	9.95	121	166187	21278	79556802
Persistent genital arousal disorder	44.23	9.95	18	166290	263	79577817
Drug withdrawal syndrome	44.16	9.95	166	166142	34552	79543528
Feeling of body temperature change	44.10	9.95	55	166253	5271	79572809
Discomfort	43.80	9.95	126	166182	125491	79452589
Impaired healing	43.76	9.95	72	166236	87583	79490497
Infection susceptibility increased	43.63	9.95	46	166262	3675	79574405
Neovascularisation	43.58	9.95	29	166279	1216	79576864
Inhibitory drug interaction	43.46	9.95	50	166258	4403	79573677
Sacroiliitis	43.29	9.95	46	166262	3708	79574372
Helicobacter infection	43.11	9.95	49	166259	69655	79508425
Neck pain	42.35	9.95	286	166022	75131	79502949
Death	42.21	9.95	881	165427	565633	79012447
Multiple drug therapy	41.86	9.95	47	166261	4031	79574049
Allergy to chemicals	41.39	9.95	38	166270	2564	79575516
Haemoglobin decreased	40.38	9.95	284	166024	221835	79356245
Respiratory failure	40.34	9.95	217	166091	180694	79397386
Respiratory depression	40.16	9.95	138	166170	27492	79550588
Bradypnoea	40.06	9.95	56	166252	5996	79572084
Pituitary tumour benign	39.77	9.95	37	166271	2539	79575541
Pneumonia	39.69	9.95	1061	165247	659185	78918895
Exposure during pregnancy	39.39	9.95	96	166212	101036	79477044
Septic shock	39.38	9.95	128	166180	122673	79455407
Oesophageal spasm	39.24	9.95	42	166266	3414	79574666
Cushingoid	39.16	9.95	71	166237	9481	79568599
Small fibre neuropathy	38.46	9.95	20	166288	526	79577554
Allodynia	38.44	9.95	30	166278	1618	79576462
Somatic symptom disorder	38.33	9.95	36	166272	2501	79575579
Hyperaesthesia	38.15	9.95	81	166227	12141	79565939
Wrist deformity	37.80	9.95	33	166275	2084	79575996
Blood bilirubin increased	37.34	9.95	50	166258	66182	79511898
Vision blurred	37.30	9.95	361	165947	105537	79472543
Bursitis	37.30	9.95	161	166147	35683	79542397
Sensory loss	37.03	9.95	83	166225	12908	79565172
Synovial cyst	36.52	9.95	71	166237	9994	79568086
Therapeutic product ineffective	36.42	9.95	31	166277	1891	79576189
Oedema	36.06	9.95	128	166180	119452	79458628
Pleural effusion	35.95	9.95	168	166140	145094	79432986
Pancytopenia	35.75	9.95	201	166107	165544	79412536
Contraindicated product administered	35.66	9.95	188	166120	157350	79420730
Brain injury	35.57	9.95	76	166232	11441	79566639
Menstrual disorder	35.29	9.95	43	166265	4024	79574056
Tenderness	35.17	9.95	119	166189	23523	79554557
Haemorrhage	35.09	9.95	87	166221	91031	79487049
Heart sounds	35.02	9.95	23	166285	943	79577137
Cardiac failure	34.93	9.95	185	166123	154657	79423423
Knee arthroplasty	34.43	9.95	24	166284	43224	79534856
Cestode infection	34.38	9.95	15	166293	263	79577817
Dysarthria	34.19	9.95	250	166058	67372	79510708
Myoclonus	34.15	9.95	131	166177	27529	79550551
Headache	34.08	9.95	1678	164630	652094	78925986
Hip arthroplasty	33.95	9.95	16	166292	35740	79542340
Condition aggravated	33.95	9.95	791	165517	500333	79077747
Psychotic disorder due to a general medical condition	33.72	9.95	15	166293	276	79577804
Renal impairment	33.68	9.95	192	166116	157591	79420489
Labelled drug-drug interaction issue	33.56	9.95	26	166282	1387	79576693
Oesophageal pain	33.54	9.95	43	166265	4236	79573844
Neuralgia	33.25	9.95	148	166160	33236	79544844
Crystal nephropathy	32.89	9.95	26	166282	1429	79576651
Cervix neoplasm	32.58	9.95	13	166295	180	79577900
Parosmia	32.48	9.95	55	166253	6959	79571121
Leukopenia	32.35	9.95	129	166179	116384	79461696
Irritable bowel syndrome	32.12	9.95	50	166258	62191	79515889
Transient ischaemic attack	32.11	9.95	204	166104	52491	79525589
Muscular weakness	32.08	9.95	492	165816	160237	79417843
Paraesthesia	31.91	9.95	531	165777	175792	79402288
Deep vein thrombosis	31.63	9.95	137	166171	120782	79457298
Hyperlactacidaemia	31.56	9.95	48	166260	5547	79572533
Tenosynovitis	31.28	9.95	87	166221	15467	79562613
Hepatic function abnormal	31.23	9.95	66	166242	73041	79505039
Abdominal discomfort	30.89	9.95	354	165954	250373	79327707
Muscle disorder	30.84	9.95	48	166260	5659	79572421
Swelling	30.75	9.95	296	166012	216415	79361665
Rash papular	30.59	9.95	108	166200	21808	79556272
Clear cell renal cell carcinoma	30.48	9.95	32	166276	2544	79575536
Bone marrow failure	30.45	9.95	37	166271	51070	79527010
Sopor	30.40	9.95	143	166165	32867	79545213
Autonomic dysreflexia	30.38	9.95	16	166292	432	79577648
Accidental death	30.36	9.95	41	166267	4250	79573830
Cytokine release syndrome	29.98	9.95	19	166289	35979	79542101
Disseminated intravascular coagulation	29.73	9.95	19	166289	35823	79542257
Lymphoedema	29.62	9.95	74	166234	12339	79565741
Haematuria	29.52	9.95	62	166246	68774	79509306
Product used for unknown indication	29.46	9.95	25	166283	1519	79576561
Prolonged expiration	29.35	9.95	23	166285	1248	79576832
Lymphadenitis	29.23	9.95	42	166266	4613	79573467
Hospitalisation	28.99	9.95	100	166208	94136	79483944
Eye irritation	28.94	9.95	102	166206	20579	79557501
Multiple sclerosis relapse	28.89	9.95	181	166127	46352	79531728
Gastrointestinal haemorrhage	28.77	9.95	185	166123	147534	79430546
Liver injury	28.72	9.95	46	166262	56568	79521512
Urinary retention	28.42	9.95	209	166099	56421	79521659
Drooling	28.10	9.95	47	166261	5887	79572193
Pulmonary embolism	28.09	9.95	226	166082	171428	79406652
Impaired reasoning	27.98	9.95	10	166298	100	79577980
Loss of consciousness	27.94	9.95	499	165809	167444	79410636
Antinuclear antibody positive	27.83	9.95	55	166253	7835	79570245
Decreased appetite	27.71	9.95	525	165783	341893	79236187
Infection	27.59	9.95	347	165961	241365	79336715
Akathisia	27.49	9.95	75	166233	13184	79564896
Speech disorder	27.36	9.95	201	166107	54244	79523836
Blister	27.36	9.95	142	166166	119334	79458746
Blood urea increased	27.34	9.95	37	166271	48753	79529327
Pneumocystis jirovecii pneumonia	27.29	9.95	17	166291	32491	79545589
Delusion of replacement	27.20	9.95	11	166297	158	79577922
Premenstrual syndrome	26.89	9.95	16	166292	550	79577530
Aspergillus infection	26.76	9.95	4	166304	19157	79558923
Pulmonary hypertension	26.40	9.95	37	166271	48043	79530037
Therapy non-responder	26.38	9.95	101	166207	92204	79485876
Conjunctivitis	26.37	9.95	115	166193	25600	79552480
Incontinence	26.32	9.95	77	166231	14087	79563993
Pyrexia	26.20	9.95	1153	165155	677556	78900524
Ascites	26.18	9.95	76	166232	75486	79502594
Hyperthermia	26.14	9.95	90	166218	17947	79560133
Prostate cancer	25.78	9.95	19	166289	33249	79544831
Glucose tolerance impaired	25.72	9.95	54	166254	8030	79570050
Pulmonary eosinophilia	25.31	9.95	17	166291	724	79577356
Head discomfort	25.21	9.95	77	166231	14425	79563655
Tension	25.15	9.95	38	166270	4366	79573714
Eyelid exfoliation	24.83	9.95	10	166298	142	79577938
Cardio-respiratory arrest	24.75	9.95	340	165968	108170	79469910
Nephrolithiasis	24.68	9.95	193	166115	53098	79524982
Delirium	24.38	9.95	277	166031	84350	79493730
Substance abuse	24.33	9.95	62	166246	10464	79567616
Back pain	24.18	9.95	817	165491	303363	79274717
Asthenia	24.14	9.95	849	165459	510840	79067240
CFTR gene mutation	23.94	9.95	9	166299	105	79577975
Diaphragmatic rupture	23.89	9.95	11	166297	220	79577860
Paralysis	23.88	9.95	71	166237	13106	79564974
Red blood cell sedimentation rate increased	23.62	9.95	37	166271	45905	79532175
Diet failure	23.28	9.95	7	166301	38	79578042
Bladder cancer	23.24	9.95	6	166302	19520	79558560
Dental restoration failure	23.14	9.95	18	166290	966	79577114
Dyskinesia	22.90	9.95	166	166142	44607	79533473
Joint effusion	22.80	9.95	86	166222	17928	79560152
Bronchopulmonary aspergillosis	22.72	9.95	9	166299	22285	79555795
Drug interaction	22.71	9.95	1071	165237	414112	79163968
Soft tissue injury	22.65	9.95	23	166285	1758	79576322
Sensitivity to weather change	22.47	9.95	51	166257	7996	79570084
Angioedema	22.41	9.95	250	166058	75785	79502295
Adverse event	22.02	9.95	59	166249	60155	79517925
Product use issue	21.83	9.95	307	166001	209515	79368565
Dry mouth	21.82	9.95	280	166028	87739	79490341
Peritonitis	21.74	9.95	16	166292	28020	79550060
Drug resistance	21.70	9.95	34	166274	42179	79535901
International normalised ratio increased	21.54	9.95	97	166211	84624	79493456
Pregnancy	21.24	9.95	15	166293	26836	79551244
Device expulsion	21.06	9.95	14	166294	25847	79552233
Rash	20.99	9.95	989	165319	577369	79000711
Hostility	20.98	9.95	25	166283	2285	79575795
Migraine with aura	20.92	9.95	27	166281	2678	79575402
Hypotension	20.81	9.95	1120	165188	439197	79138883
Palmar-plantar erythrodysaesthesia syndrome	20.81	9.95	23	166285	33111	79544969
Biliary sepsis	20.78	9.95	21	166287	1596	79576484
Peripheral venous disease	20.72	9.95	4	166304	15905	79562175
Dry eye	20.69	9.95	140	166168	36791	79541289
Shock haemorrhagic	20.60	9.95	8	166300	20052	79558028
Cerebral infarction	20.56	9.95	40	166268	45636	79532444
Diarrhoea	20.53	9.95	1570	164738	878919	78699161
White blood cell count increased	20.48	9.95	83	166225	74550	79503530
Mood swings	20.46	9.95	89	166219	19791	79558289
Eyelid myoclonus	20.43	9.95	8	166300	105	79577975
Panic attack	20.21	9.95	102	166206	24114	79553966
Myelodysplastic syndrome	20.19	9.95	20	166288	30281	79547799
Hypoaesthesia oral	20.05	9.95	70	166238	14054	79564026
Circulatory collapse	20.05	9.95	141	166167	37527	79540553
Haematoma	19.97	9.95	50	166258	52145	79525935
Unevaluable event	19.93	9.95	55	166253	55530	79522550
Alopecia	19.86	9.95	351	165957	231004	79347076
Accidental overdose	19.81	9.95	146	166162	39435	79538645
Patient dissatisfaction with treatment	19.69	9.95	9	166299	177	79577903
CYP3A4 polymorphism	19.59	9.95	7	166301	70	79578010
Mental disorder	19.58	9.95	122	166186	31180	79546900
Postural orthostatic tachycardia syndrome	19.55	9.95	16	166292	924	79577156
Sinus tachycardia	19.55	9.95	138	166170	36770	79541310
HIV peripheral neuropathy	19.45	9.95	6	166302	36	79578044
Multiple sclerosis	19.41	9.95	95	166213	22187	79555893
Electrocardiogram PR prolongation	19.33	9.95	20	166288	1563	79576517
Staphylococcal infection	19.22	9.95	60	166248	58235	79519845
Sternal fracture	19.17	9.95	25	166283	2505	79575575
Haemodialysis	19.07	9.95	7	166301	18161	79559919
Drug dependence	19.07	9.95	148	166160	40621	79537459
Injection site erythema	19.01	9.95	91	166217	78106	79499974
Subclavian artery embolism	18.97	9.95	5	166303	15	79578065
Premature labour	18.96	9.95	49	166259	8341	79569739
Plasma cell myeloma	18.87	9.95	53	166255	53206	79524874
Breath sounds abnormal	18.85	9.95	5	166303	15979	79562101
Acute myeloid leukaemia	18.78	9.95	22	166286	30863	79547217
Lichen sclerosus	18.77	9.95	16	166292	978	79577102
Abdominal pain upper	18.76	9.95	605	165703	223214	79354866
Alcoholic ketoacidosis	18.73	9.95	5	166303	16	79578064
Pericardial effusion	18.71	9.95	43	166265	46194	79531886
Polymenorrhoea	18.66	9.95	16	166292	986	79577094
Pulmonary arterial hypertension	18.58	9.95	19	166289	28347	79549733
Respiratory distress	18.56	9.95	61	166247	58278	79519802
CADASIL	18.54	9.95	6	166302	43	79578037
Anaphylactic shock	18.49	9.95	29	166279	35967	79542113
Drug eruption	18.48	9.95	40	166268	43895	79534185
Thymus disorder	18.44	9.95	10	166298	287	79577793
Depression	18.43	9.95	587	165721	216203	79361877
Femoral artery dissection	18.30	9.95	6	166302	45	79578035
Enterococcal infection	18.28	9.95	5	166303	15655	79562425
Depressive symptom	18.26	9.95	41	166267	6382	79571698
Vascular malformation	18.26	9.95	11	166297	387	79577693
Magnesium deficiency	18.22	9.95	13	166295	611	79577469
Respiration abnormal	18.13	9.95	46	166262	7742	79570338
Slow speech	18.02	9.95	24	166284	2454	79575626
Neurotoxicity	17.87	9.95	25	166283	32493	79545587
Vulvovaginal swelling	17.83	9.95	11	166297	404	79577676
Hyperbilirubinaemia	17.74	9.95	15	166293	24503	79553577
Therapeutic product effect decreased	17.67	9.95	238	166070	163625	79414455
Visual snow syndrome	17.35	9.95	6	166302	54	79578026
Tubulointerstitial nephritis and uveitis syndrome	17.31	9.95	10	166298	325	79577755
Limb injury	17.18	9.95	113	166195	29415	79548665
Poliomyelitis	17.15	9.95	6	166302	56	79578024
Cerebellar stroke	17.14	9.95	12	166296	547	79577533
Food refusal	17.13	9.95	12	166296	548	79577532
Libido increased	17.11	9.95	21	166287	1980	79576100
Anaemia of malignant disease	17.07	9.95	14	166294	811	79577269
Anterograde amnesia	17.04	9.95	13	166295	678	79577402
Paranasal cyst	16.90	9.95	11	166297	444	79577636
Gout	16.88	9.95	16	166292	24733	79553347
Agoraphobia	16.78	9.95	12	166296	566	79577514
Post procedural complication	16.73	9.95	15	166293	23814	79554266
Hypovolaemia	16.67	9.95	8	166300	17683	79560397
Vaccination site bruising	16.67	9.95	4	166304	7	79578073
Product dose omission issue	16.64	9.95	391	165917	247146	79330934
Renal mass	16.55	9.95	27	166281	3313	79574767
Post-traumatic neck syndrome	16.35	9.95	21	166287	2073	79576007
Therapy interrupted	16.34	9.95	25	166283	31316	79546764
Vaccination site oedema	16.32	9.95	4	166304	8	79578072
Colitis	16.29	9.95	88	166220	73219	79504861
Cyanosis	16.29	9.95	99	166209	25083	79552997
Bradyphrenia	16.22	9.95	54	166254	10586	79567494
Blood uric acid increased	16.10	9.95	4	166304	13356	79564724
Genital infection female	16.04	9.95	6	166302	69	79578011
Dyspnoea exertional	15.97	9.95	111	166197	86962	79491118
Skin necrosis	15.83	9.95	9	166299	18078	79560002
Dry age-related macular degeneration	15.76	9.95	9	166299	286	79577794
Treatment noncompliance	15.72	9.95	56	166252	52212	79525868
Hypohidrosis	15.71	9.95	9	166299	288	79577792
Pulmonary fibrosis	15.55	9.95	44	166264	44068	79534012
Haemoptysis	15.54	9.95	62	166246	55937	79522143
Respiratory arrest	15.52	9.95	186	166122	57364	79520716
Live birth	15.46	9.95	10	166298	18734	79559346
Vaccination site pruritus	15.44	9.95	4	166304	11	79578069
Adiposis dolorosa	15.27	9.95	9	166299	304	79577776
Impaired quality of life	15.26	9.95	65	166243	14321	79563759
Ill-defined disorder	15.24	9.95	78	166230	65797	79512283
Femoral nerve palsy	15.17	9.95	6	166302	81	79577999
Burning sensation	15.16	9.95	188	166120	58444	79519636
Dialysis	15.02	9.95	10	166298	18452	79559628
Pulmonary haemorrhage	14.90	9.95	6	166302	14711	79563369
Carbon dioxide abnormal	14.89	9.95	10	166298	426	79577654
Mood altered	14.77	9.95	75	166233	17772	79560308
Eosinophilia	14.71	9.95	47	166261	45298	79532782
Dry skin	14.67	9.95	211	166097	67784	79510296
Pulmonary alveolar haemorrhage	14.67	9.95	3	166305	11454	79566626
Musculoskeletal stiffness	14.64	9.95	473	165835	174535	79403545
Acute respiratory failure	14.64	9.95	69	166239	59472	79518608
Vestibular migraine	14.64	9.95	7	166301	153	79577927
Nodule	14.62	9.95	90	166218	22904	79555176
Tumour lysis syndrome	14.61	9.95	17	166291	23922	79554158
Hyperprolactinaemia	14.61	9.95	31	166277	4645	79573435
Haematocrit decreased	14.53	9.95	72	166236	61240	79516840
Hepatic failure	14.43	9.95	72	166236	61140	79516940
Anti-neutrophil cytoplasmic antibody positive vasculitis	14.38	9.95	27	166281	3702	79574378
Metastases to liver	14.37	9.95	23	166285	28291	79549789
Vertigo	14.37	9.95	213	166095	68869	79509211
Mouth swelling	14.36	9.95	36	166272	6015	79572065
Maternal condition affecting foetus	14.31	9.95	7	166301	161	79577919
Concussion	14.28	9.95	48	166260	9455	79568625
SLE arthritis	14.28	9.95	11	166297	582	79577498
Interstitial lung disease	14.24	9.95	158	166150	112442	79465638
Type 2 diabetes mellitus	14.16	9.95	66	166242	57056	79521024
Basal cell carcinoma	14.14	9.95	36	166272	37339	79540741
Wrong technique in product usage process	14.13	9.95	93	166215	73782	79504298
Abnormal loss of weight	14.12	9.95	44	166264	8332	79569748
Pericarditis	14.09	9.95	144	166164	104092	79473988
Rectal cancer metastatic	14.09	9.95	10	166298	466	79577614
Muscle spasms	14.04	9.95	470	165838	174260	79403820
Personality disorder	14.00	9.95	36	166272	6110	79571970
Oesophageal carcinoma	13.99	9.95	3	166305	11081	79566999
Injection site swelling	13.84	9.95	51	166257	47081	79530999
Procedural anxiety	13.80	9.95	12	166296	754	79577326
Stomatitis	13.78	9.95	219	166089	146538	79431542
Restlessness	13.76	9.95	153	166155	46339	79531741
Nail injury	13.72	9.95	11	166297	617	79577463
Bacteraemia	13.71	9.95	30	166278	32794	79545286
Post-traumatic stress disorder	13.70	9.95	31	166277	4850	79573230
Rectal haemorrhage	13.63	9.95	98	166210	76202	79501878
Drug tolerance decreased	13.62	9.95	5	166303	12973	79565107
Haematochezia	13.60	9.95	117	166191	87528	79490552
Complication associated with device	13.55	9.95	10	166298	17486	79560594
Quality of life decreased	13.40	9.95	50	166258	10370	79567710
Hot flush	13.35	9.95	174	166134	54703	79523377
Hyperuricaemia	13.34	9.95	4	166304	11795	79566285
Hypervolaemia	13.33	9.95	45	166263	42645	79535435
Ejection fraction decreased	13.32	9.95	33	166275	34544	79543536
Transaminases increased	13.30	9.95	59	166249	51684	79526396
Metastases to lung	13.28	9.95	11	166297	18152	79559928
Autonomic neuropathy	13.24	9.95	18	166290	1877	79576203
Coma scale abnormal	13.19	9.95	44	166264	8634	79569446
Blood lactate dehydrogenase increased	13.13	9.95	40	166268	39130	79538950
Right ventricular failure	12.98	9.95	18	166290	23479	79554601
Hepatotoxicity	12.93	9.95	59	166249	51293	79526787
Haemolysis	12.91	9.95	57	166251	12755	79565325
Sleep deficit	12.84	9.95	14	166294	1162	79576918
Naevus haemorrhage	12.81	9.95	6	166302	125	79577955
Haemophagocytic lymphohistiocytosis	12.81	9.95	16	166292	21821	79556259
Second primary malignancy	12.76	9.95	7	166301	14343	79563737
Metastases to lymph nodes	12.75	9.95	3	166305	10394	79567686
Cystitis interstitial	12.62	9.95	15	166293	1368	79576712
Mast cell degranulation present	12.61	9.95	5	166303	68	79578012
Hypoxia	12.61	9.95	146	166162	103097	79474983
Drug dispensed to wrong patient	12.59	9.95	11	166297	695	79577385
Pseudomonas infection	12.59	9.95	15	166293	20888	79557192
Myoglobin urine	12.57	9.95	4	166304	27	79578053
Appetite disorder	12.45	9.95	40	166268	7699	79570381
Blood pressure decreased	12.41	9.95	140	166168	99326	79478754
Acute graft versus host disease	12.34	9.95	3	166305	10164	79567916
Blood alkaline phosphatase increased	12.25	9.95	80	166228	63584	79514496
Menstruation delayed	12.25	9.95	15	166293	1411	79576669
Myofascial pain syndrome	12.24	9.95	18	166290	2019	79576061
Forced expiratory volume decreased	12.22	9.95	40	166268	7774	79570306
Poor peripheral circulation	12.19	9.95	25	166283	3658	79574422
Hyperammonaemia	12.12	9.95	4	166304	11089	79566991
Urticaria aquagenic	12.09	9.95	4	166304	31	79578049
Sleep disorder	12.00	9.95	248	166060	85429	79492651
Urticaria cholinergic	11.98	9.95	4	166304	32	79578048
Dysphemia	11.94	9.95	24	166284	3460	79574620
Metastases to central nervous system	11.87	9.95	10	166298	16365	79561715
Oliguria	11.77	9.95	10	166298	16299	79561781
Full blood count abnormal	11.75	9.95	44	166264	40430	79537650
Diaphragmatic paralysis	11.73	9.95	13	166295	1099	79576981
Injection site reaction	11.50	9.95	67	166241	54718	79523362
Behaviour disorder	11.42	9.95	34	166274	6279	79571801
Acute lung injury	11.41	9.95	22	166286	3078	79575002
Oral herpes	11.40	9.95	97	166211	27357	79550723
Injury	11.34	9.95	105	166203	77391	79500689
Faecaloma	11.31	9.95	51	166257	11513	79566567
Binge eating	11.30	9.95	9	166299	500	79577580
Sinoatrial block	11.26	9.95	14	166294	1337	79576743
Acquired diaphragmatic eventration	11.23	9.95	10	166298	648	79577432
Infrapatellar fat pad inflammation	11.23	9.95	6	166302	167	79577913
Phonophobia	11.19	9.95	9	166299	507	79577573
Activated partial thromboplastin time prolonged	11.19	9.95	8	166300	14220	79563860
Pharyngeal oedema	11.18	9.95	65	166243	16207	79561873
Bacterial infection	11.17	9.95	31	166277	31249	79546831
Synovial disorder	11.17	9.95	17	166291	1966	79576114
Sports injury	11.13	9.95	6	166302	170	79577910
Viral diarrhoea	11.12	9.95	8	166300	381	79577699
Cerebrovascular accident	11.08	9.95	243	166065	155049	79423031
Acute myocardial infarction	11.01	9.95	105	166203	76931	79501149
Urticaria	10.97	9.95	298	166010	184903	79393177
Sinusitis	10.96	9.95	317	165991	195184	79382896
Parkinsonian rest tremor	10.95	9.95	7	166301	274	79577806
Iron binding capacity total decreased	10.94	9.95	8	166300	391	79577689
Gastrointestinal disorder	10.93	9.95	184	166124	122021	79456059
Muscle rigidity	10.92	9.95	75	166233	19807	79558273
Lipase increased	10.82	9.95	11	166297	16455	79561625
Blood creatine phosphokinase increased	10.81	9.95	87	166221	66003	79512077
Hospice care	10.80	9.95	4	166304	10320	79567760
Candida infection	10.80	9.95	42	166266	38172	79539908
Venous angioma of brain	10.69	9.95	4	166304	46	79578034
Nail bed tenderness	10.67	9.95	8	166300	406	79577674
Allergic sinusitis	10.67	9.95	11	166297	856	79577224
Onychophagia	10.64	9.95	5	166303	105	79577975
Intraocular pressure increased	10.63	9.95	3	166305	9202	79568878
Disorientation	10.60	9.95	187	166121	62589	79515491
Cystitis haemorrhagic	10.57	9.95	3	166305	9169	79568911
Benzodiazepine drug level therapeutic	10.54	9.95	4	166304	48	79578032
Laryngeal dyspnoea	10.51	9.95	7	166301	294	79577786
Metastases to bone	10.47	9.95	22	166286	24405	79553675
Wrong patient received product	10.47	9.95	27	166281	4591	79573489
Lenticular opacities	10.45	9.95	9	166299	558	79577522
Oxalosis	10.43	9.95	5	166303	110	79577970
Injection site bruising	10.39	9.95	47	166261	40955	79537125
Heliotrope rash	10.36	9.95	6	166302	196	79577884
Burning feet syndrome	10.30	9.95	6	166302	198	79577882
Epistaxis	10.27	9.95	167	166141	111348	79466732
Enlarged uvula	10.24	9.95	8	166300	432	79577648
Organising pneumonia	10.23	9.95	5	166303	10934	79567146
Sensory disturbance	10.22	9.95	60	166248	15017	79563063
Tender joint count	10.17	9.95	6	166302	203	79577877
Miosis	10.17	9.95	62	166246	15727	79562353
Hypoalbuminaemia	10.16	9.95	18	166290	21279	79556801
Chemical burns of eye	10.11	9.95	5	166303	118	79577962
Mania	10.10	9.95	69	166239	18191	79559889
Venoocclusive liver disease	10.10	9.95	6	166302	11765	79566315
Melaena	10.03	9.95	80	166228	60810	79517270
Lactic acidosis	10.01	9.95	96	166212	70263	79507817

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	N06AA09	NERVOUS SYSTEM PSYCHOANALEPTICS ANTIDEPRESSANTS Non-selective monoamine reuptake inhibitors
ATC	N06CA01	NERVOUS SYSTEM PSYCHOANALEPTICS PSYCHOLEPTICS AND PSYCHOANALEPTICS IN COMBINATION Antidepressants in combination with psycholeptics
CHEBI has role	CHEBI:35469	antidepressants
CHEBI has role	CHEBI:35640	adrenergic uptake inhibitors
CHEBI has role	CHEBI:35703	Xenobiotic
CHEBI has role	CHEBI:78298	environmental contaminants
CHEBI has role	CHEBI:140489	TrkB receptor agonist
MeSH PA	D018663	Adrenergic Agents
MeSH PA	D018759	Adrenergic Uptake Inhibitors
MeSH PA	D000700	Analgesics
MeSH PA	D018712	Analgesics, Non-Narcotic
MeSH PA	D000928	Antidepressive Agents
MeSH PA	D000929	Antidepressive Agents, Tricyclic
MeSH PA	D002491	Central Nervous System Agents
MeSH PA	D049990	Membrane Transport Modulators
MeSH PA	D018377	Neurotransmitter Agents
MeSH PA	D014179	Neurotransmitter Uptake Inhibitors
MeSH PA	D018373	Peripheral Nervous System Agents
MeSH PA	D011619	Psychotropic Drugs
MeSH PA	D018689	Sensory System Agents
FDA EPC	N0000175752	Tricyclic Antidepressant

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Depressive disorder	indication	35489007
Mixed anxiety and depressive disorder	indication	231504006
Posttraumatic stress disorder	off-label use	47505003	DOID:2055
Bulimia nervosa	off-label use	78004001
Fibromyalgia	off-label use	203082005	DOID:631
Neuropathic pain	off-label use	247398009
Migraine Prevention	off-label use
Suicidal thoughts	contraindication	6471006
Alcoholism	contraindication	7200002
Organophosphate poisoning	contraindication	8260003
Weight gain finding	contraindication	8943002
Sinus tachycardia	contraindication	11092001
Neuroleptic malignant syndrome	contraindication	15244003	DOID:14464
Senile dementia	contraindication	15662003
Chronic disease of respiratory system	contraindication	17097001
Disorder of lung	contraindication	19829001	DOID:850
Myocardial infarction	contraindication	22298006	DOID:5844
Glaucoma	contraindication	23986001	DOID:1686
Alcohol intoxication	contraindication	25702006
Shock	contraindication	27942005
Orthostatic hypotension	contraindication	28651003
Torsades de pointes	contraindication	31722008
Parkinsonism	contraindication	32798002
Hyperthyroidism	contraindication	34486009	DOID:7998
Hyperactive behavior	contraindication	44548000
Conduction disorder of the heart	contraindication	44808001
Chronic heart failure	contraindication	48447003
Bradycardia	contraindication	48867003
Paralytic ileus	contraindication	55525008	DOID:8442
Substance abuse	contraindication	66214007
Psychotic disorder	contraindication	69322001
Sleep apnea	contraindication	73430006	DOID:0050847
Extrapyramidal disease	contraindication	76349003
Hyperglycemia	contraindication	80394007	DOID:4195
Chronic idiopathic constipation	contraindication	82934008
Open-angle glaucoma	contraindication	84494001	DOID:1067
Epilepsy	contraindication	84757009	DOID:1826
Leukopenia	contraindication	84828003	DOID:615
Stupor	contraindication	89458003
Kidney disease	contraindication	90708001	DOID:557
Tardive dyskinesia	contraindication	102449007
Prolonged QT interval	contraindication	111975006
Hypoalbuminemia	contraindication	119247004
Acute disease of cardiovascular system	contraindication	128487001
Bipolar affective disorder, current episode manic	contraindication	191618007
Angina pectoris	contraindication	194828000
Disease of liver	contraindication	235856003	DOID:409
Metabolic syndrome X	contraindication	237602007	DOID:14221
Hyperprolactinemia	contraindication	237662005	DOID:12700
Benign prostatic hyperplasia	contraindication	266569009
Retention of urine	contraindication	267064002
Syncope	contraindication	271594007
Anemia	contraindication	271737000	DOID:2355
Pregnancy, function	contraindication	289908002
Thrombocytopenic disorder	contraindication	302215000	DOID:1588
Neutropenic disorder	contraindication	303011007	DOID:1227
Severe chronic obstructive pulmonary disease	contraindication	313299006
Coma	contraindication	371632003
At risk for aspiration	contraindication	371736008
Angle-closure glaucoma	contraindication	392291006	DOID:13550
Visual impairment	contraindication	397540003
Breastfeeding (mother)	contraindication	413712001
Myocardial ischemia	contraindication	414795007	DOID:3393
Obesity	contraindication	414916001	DOID:9970
Myocardial infarction in recovery phase	contraindication	418044006
Porphyria	contraindication	418470004
Congenital long QT syndrome	contraindication	442917000
Carcinoma of female breast	contraindication	447782002

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	8.66	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Bioact source	MoA source
Sodium-dependent noradrenaline transporter	Transporter	P23975	SC6A2_HUMAN	INHIBITOR	Kd	7.46	WOMBAT-PK	CHEMBL
Sodium-dependent serotonin transporter	Transporter	P31645	SC6A4_HUMAN	INHIBITOR	Kd	8.37	WOMBAT-PK	CHEMBL
D(2) dopamine receptor	GPCR	P14416	DRD2_HUMAN		Ki	6.71	WOMBAT-PK
Alpha-2A adrenergic receptor	GPCR	P08913	ADA2A_HUMAN		Ki	6.88	DRUG MATRIX
Sigma non-opioid intracellular receptor 1	Membrane receptor	Q99720	SGMR1_HUMAN		IC50	6.25	WOMBAT-PK
Potassium voltage-gated channel subfamily H member 2	Ion channel	Q12809	KCNH2_HUMAN		IC50	5	WOMBAT-PK
5-hydroxytryptamine receptor 1A	GPCR	P08908	5HT1A_HUMAN		Ki	6.72	WOMBAT-PK
5-hydroxytryptamine receptor 2A	GPCR	P28223	5HT2A_HUMAN		Ki	7.96	WOMBAT-PK
5-hydroxytryptamine receptor 2B	GPCR	P41595	5HT2B_HUMAN		Ki	7.40	WOMBAT-PK
5-hydroxytryptamine receptor 2C	GPCR	P28335	5HT2C_HUMAN		Ki	8.10	WOMBAT-PK
5-hydroxytryptamine receptor 6	GPCR	P50406	5HT6R_HUMAN		Ki	7.05	WOMBAT-PK
5-hydroxytryptamine receptor 7	GPCR	P34969	5HT7R_HUMAN		Ki	6.40	WOMBAT-PK
Alpha-1A adrenergic receptor	GPCR	P35348	ADA1A_HUMAN		IC50	7.90	WOMBAT-PK
Alpha-2B adrenergic receptor	GPCR	P18089	ADA2B_HUMAN		IC50	8	WOMBAT-PK
D(3) dopamine receptor	GPCR	P35462	DRD3_HUMAN		Ki	6.69	WOMBAT-PK
D(1B) dopamine receptor	GPCR	P21918	DRD5_HUMAN		Ki	6.77	WOMBAT-PK
Histamine H1 receptor	GPCR	P35367	HRH1_HUMAN	ANTAGONIST	Ki	9.30	WOMBAT-PK
Histamine H2 receptor	GPCR	P25021	HRH2_HUMAN		IC50	6.80	WOMBAT-PK
Histamine H4 receptor	GPCR	Q9H3N8	HRH4_HUMAN		Ki	8.14	WOMBAT-PK
Muscarinic acetylcholine receptor M1	GPCR	P11229	ACM1_HUMAN	ANTAGONIST	Ki	7.83	WOMBAT-PK
Muscarinic acetylcholine receptor M2	GPCR	P08172	ACM2_HUMAN		Ki	8.10	WOMBAT-PK
Muscarinic acetylcholine receptor M3	GPCR	P20309	ACM3_HUMAN		Ki	7.89	WOMBAT-PK
Muscarinic acetylcholine receptor M4	GPCR	P08173	ACM4_HUMAN		Ki	8.14	WOMBAT-PK
Muscarinic acetylcholine receptor M5	GPCR	P08912	ACM5_HUMAN		Ki	7.80	WOMBAT-PK
Aldehyde oxidase	Enzyme	Q06278	AOXA_HUMAN		IC50	6.59	WOMBAT-PK
Alpha-2C adrenergic receptor	GPCR	P18825	ADA2C_HUMAN		Ki	8.07	DRUG MATRIX
Sodium channel protein type 2 subunit alpha	Ion channel	Q99250	SCN2A_HUMAN		IC50	5.51	CHEMBL
Sodium channel protein type 9 subunit alpha	Ion channel	Q15858	SCN9A_HUMAN		IC50	6	CHEMBL
Sodium-dependent dopamine transporter	Transporter	Q01959	SC6A3_HUMAN		Ki	5.21	CHEMBL
Alpha-1D adrenergic receptor	GPCR	P25100	ADA1D_HUMAN		Ki	8.25	DRUG MATRIX
Proto-oncogene tyrosine-protein kinase receptor Ret	Kinase	P07949	RET_HUMAN		IC50	6	CHEMBL
High affinity nerve growth factor receptor	Kinase	P04629	NTRK1_HUMAN		IC50	4.22	CHEMBL
Voltage-dependent N-type calcium channel subunit alpha-1B	Ion channel	Q00975	CAC1B_HUMAN		IC50	4.92	CHEMBL
Solute carrier family 22 member 1	Transporter	O15245	S22A1_HUMAN		IC50	4.77	CHEMBL
Solute carrier family 22 member 2	Transporter	O15244	S22A2_HUMAN		IC50	4.85	WOMBAT-PK
Sodium channel protein type 5 subunit alpha	Ion channel	Q14524	SCN5A_HUMAN		IC50	5.80	CHEMBL
D(1A) dopamine receptor	GPCR	P21728	DRD1_HUMAN		Ki	7.05	WOMBAT-PK
Alpha-1B adrenergic receptor	GPCR		ADA1B_RAT		Ki	7.38	DRUG MATRIX
5-hydroxytryptamine receptor 1B	GPCR		5HT1B_RAT		Ki	5.77	DRUG MATRIX
Alpha-1A adrenergic receptor	GPCR		ADA1A_RAT		IC50	10.70	CHEMBL
5-hydroxytryptamine receptor 1A	GPCR		5HT1A_RAT		IC50	5.70	CHEMBL
Sodium-dependent serotonin transporter	Transporter		SC6A4_RAT		IC50	5.07	CHEMBL
5-hydroxytryptamine receptor 2A	GPCR		5HT2A_RAT	ANTAGONIST	Ki	8.40	IUPHAR
Transporter	Transporter		Q9WTR4_RAT		IC50	5.60	CHEMBL
5-hydroxytryptamine receptor 7	GPCR		5HT7R_RAT	ANTAGONIST	Ki	7	IUPHAR
5-hydroxytryptamine receptor 7	GPCR		5HT7R_MOUSE	ANTAGONIST	Ki	6.40	IUPHAR
5-hydroxytryptamine receptor 2C	GPCR		5HT2C_RAT	ANTAGONIST	Ki	8.10	IUPHAR
Histamine H1 receptor	GPCR		HRH1_RAT		IC50	10.70	CHEMBL
5-hydroxytryptamine receptor 6	GPCR		5HT6R_RAT	ANTAGONIST	Ki	7.20	IUPHAR
Muscarinic acetylcholine receptor	GPCR		ACM1_RAT ACM3_RAT ACM4_RAT ACM5_RAT ACM2_RAT		IC50	6.52	CHEMBL
G protein-activated inward rectifier potassium channel 2	Ion channel		KCNJ6_MOUSE	BLOCKER	IC50	4	IUPHAR

External reference:

ID	Source
4019607	VUID
N0000147702	NUI
D00809	KEGG_DRUG
549-18-8	SECONDARY_CAS_RN
203168	RXNORM
C0002600	UMLSCUI
CHEBI:2666	CHEBI
TP0	PDB_CHEM_ID
CHEMBL629	ChEMBL_ID
DB00321	DRUGBANK_ID
CHEMBL1200964	ChEMBL_ID
D000639	MESH_DESCRIPTOR_UI
2160	PUBCHEM_CID
200	IUPHAR_LIGAND_ID
976	INN_ID
1806D8D52K	UNII
4178	MMSL
4240	MMSL
d00146	MMSL
372726002	SNOMEDCT_US
40589005	SNOMEDCT_US
48384000	SNOMEDCT_US
4017743	VANDF
4019607	VANDF
001501	NDDF
004600	NDDF

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Perphenazine and Amitriptyline Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	2	0378-0042	TABLET, FILM COATED	10 mg	ORAL	ANDA	20 sections
Perphenazine and Amitriptyline Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	2	0378-0042	TABLET, FILM COATED	10 mg	ORAL	ANDA	20 sections
Perphenazine and Amitriptyline Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	2	0378-0073	TABLET, FILM COATED	50 mg	ORAL	ANDA	20 sections
Perphenazine and Amitriptyline Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	2	0378-0073	TABLET, FILM COATED	50 mg	ORAL	ANDA	20 sections
Chlordiazepoxide and Amitriptyline Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	2	0378-0211	TABLET, FILM COATED	14 mg	ORAL	ANDA	25 sections
Chlordiazepoxide and Amitriptyline Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	2	0378-0211	TABLET, FILM COATED	14 mg	ORAL	ANDA	25 sections
Chlordiazepoxide and Amitriptyline Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	2	0378-0211	TABLET, FILM COATED	14 mg	ORAL	ANDA	25 sections
Chlordiazepoxide and Amitriptyline Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	2	0378-0277	TABLET, FILM COATED	27.98 mg	ORAL	ANDA	25 sections
Chlordiazepoxide and Amitriptyline Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	2	0378-0277	TABLET, FILM COATED	27.98 mg	ORAL	ANDA	25 sections
Chlordiazepoxide and Amitriptyline Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	2	0378-0277	TABLET, FILM COATED	27.98 mg	ORAL	ANDA	25 sections
Perphenazine and Amitriptyline Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	2	0378-0330	TABLET, FILM COATED	10 mg	ORAL	ANDA	20 sections
Perphenazine and Amitriptyline Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	2	0378-0330	TABLET, FILM COATED	10 mg	ORAL	ANDA	20 sections
Perphenazine and Amitriptyline Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	2	0378-0442	TABLET, FILM COATED	25 mg	ORAL	ANDA	20 sections
Perphenazine and Amitriptyline Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	2	0378-0442	TABLET, FILM COATED	25 mg	ORAL	ANDA	20 sections
Perphenazine and Amitriptyline Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	2	0378-0574	TABLET, FILM COATED	25 mg	ORAL	ANDA	20 sections
Perphenazine and Amitriptyline Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	2	0378-0574	TABLET, FILM COATED	25 mg	ORAL	ANDA	20 sections
Amitriptyline Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0463-6351	TABLET, FILM COATED	25 mg	ORAL	ANDA	23 sections
Amitriptyline Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0463-6352	TABLET, FILM COATED	50 mg	ORAL	ANDA	23 sections
Amitriptyline Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0463-6354	TABLET, FILM COATED	100 mg	ORAL	ANDA	23 sections
Amitriptyline Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0603-2212	TABLET, FILM COATED	10 mg	ORAL	ANDA	23 sections
Amitriptyline Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0603-2212	TABLET, FILM COATED	10 mg	ORAL	ANDA	23 sections
Amitriptyline Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0603-2213	TABLET, FILM COATED	25 mg	ORAL	ANDA	23 sections
Amitriptyline Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0603-2213	TABLET, FILM COATED	25 mg	ORAL	ANDA	23 sections
Amitriptyline Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0603-2214	TABLET, FILM COATED	50 mg	ORAL	ANDA	23 sections
Amitriptyline Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0603-2214	TABLET, FILM COATED	50 mg	ORAL	ANDA	23 sections
Amitriptyline Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0603-2215	TABLET, FILM COATED	75 mg	ORAL	ANDA	23 sections
Amitriptyline Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0603-2215	TABLET, FILM COATED	75 mg	ORAL	ANDA	23 sections
Amitriptyline Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0603-2216	TABLET, FILM COATED	100 mg	ORAL	ANDA	23 sections
Amitriptyline Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0603-2216	TABLET, FILM COATED	100 mg	ORAL	ANDA	23 sections
Amitriptyline Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0603-2217	TABLET, FILM COATED	150 mg	ORAL	ANDA	23 sections